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Aerosol better than subcutaneous delivery for measles booster.
2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Researchers have performed immunologic studies of specific mucosal and systemic immune responses in Mexican school children after booster aerosol or subcutaneous immunization with measles vaccine.
According to recent research published in the journal Vaccine, "The purpose of the present study was to compare serum and mucosal immune responses following either aerosol (Aer) or subcutaneous (SQ) measles immunization of Mexican school children. A cohort of 49 children from 6 to 7 years of age received either Aer (n=22) or SQ (n=27) Edmonston-Zagreb (EZ) measles vaccine.
"Serum and nasal secretions were collected prior to (Pre), and at 1- and 3-month intervals and analyzed for immunoglobulin (Ig) concentrations and measles specific Ig isotype-associated antibody by enzyme immunoassay (EIA)," stated Joseph A. Bellanti and colleagues at Georgetown University and the Centers for Disease Control and Prevention in the U.S. and the Instituto Nacional de Salud Publica in Mexico.
"Serum and nasal IgG and IgA antibody responses were stimulated following immunization with live, attenuated EZ measles vaccine administered either by SQ or Aer routes but these responses were significantly greater by the Aer compared to the SQ route.
"These studies ...
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Source: HighBeam Research, Aerosol better than subcutaneous delivery for measles booster.