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After coronary event, push LDL far below 100 mg/dL: the PROVE IT-TIMI 22 trial: send patients home on high-dose statins.(Low density lipoproteins)
NEW ORLEANS -- Aggressively lowering LDL cholesterol far below the currently recommended 100 mg/dL starting right after an acute coronary event further cuts the risk of death or major cardiac events, according to the findings of a landmark clinical trial.
"Starting today, patients going home after a heart attack should be given a high-dose statin regimen," Dr. Christopher P. Cannon declared at the annual meeting of the American College of Cardiology.
He was principal investigator of the Pravastatin or Atorvastatin Evaluation and Infection Therapy--Thrombolysis in Myocardial Infarction 22 (PROVE IT-TIMI 22) trial, a double-blind, randomized multinational trial in which 4,162 patients received 80 mg/day of atorvastatin or 40 mg/day of pravastatin starting within a few days of hospital discharge after an MI or unstable angina.
The study was designed to answer this question: In patients receiving gold-standard therapy that meets current recommendations, is further LDL …
