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Animal efficacy studies of smallpox vaccine candidate show positive results.
2004 MAY 14 - (NewsRx.com & NewsRx.net) -- VaxGen, Inc., (VXGN) announced top-line results from two animal studies of the effectiveness of its attenuated smallpox vaccine candidate, LC16m8.
Both studies, which were conducted in mice and rabbits, respectively, demonstrated that a single dose of LC16m8 was as effective as the currently licensed vaccine, DryVax, in protecting against a lethal poxvirus challenge.
LC16m8 is a live attenuated vaccinia vaccine and has been licensed for use in humans in Japan since 1980.
"These are the first animal efficacy studies to be reported which directly compare the effectiveness of LC16m8 and Dryvax," said Lance K. Gordon, PhD, VaxGen's president and chief executive officer.
"Results of these new studies demonstrate that the vaccine is as effective as DryVax in controlled challenge studies in two animal species."
The studies were funded by VaxGen and the National Institute of Allergy and Infectious Diseases, part of the U.S. National Institutes of Health.
VaxGen is developing LC16m8 in collaboration with the Chemo-Sero-Therapeutic Institute (Kaketsuken) of Japan.
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