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Specific chromosomes may be linked to the age at which menopause commences.
2004 MAY 6 - (NewsRx.com & NewsRx.net) -- Specific chromosomes may be linked to the age at which menopause commences.
According to published research from the The Netherlands, "age at natural menopause may be used as a parameter for evaluating the rate of ovarian aging. Environmental factors determine only a small part of the large variation in menopausal age. Studies have shown that genetic factors are likely to be involved in variation in menopausal age.
"To identify quantitative-trait loci for this trait, we performed a genome-wide linkage study with age at natural menopause as a continuous quantitative phenotype in Dutch sister pairs, through use of a selective sampling scheme. A total of 165 families were ascertained using extreme selected sampling and were genotyped for 417 markers. Data were analyzed by Haseman-Elston regression and by an adjusted variance-components analysis. Subgroup analyses for early and late menopausal age were conducted by Haseman-Elston regression," K.M. van Asselt and colleagues, University Medical Center of Utrecht, Department of Biomedical Genetics explained.
"In the adjusted variance-components analysis, 12 chromosomes had a log of odds (LOD) score of greater than or equal to 1.0. Two chromosomal regions showed suggestive linkage: 9q21.3 (LOD score 2.6) and Xp21.3 (LOD score 3.1). Haseman-Elston regression showed rather similar locations of the peaks but yielded lower LOD scores. A permutation test to obtain empirical P values resulted in a significant peak on ...
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Source: HighBeam Research, Specific chromosomes may be linked to the age at which menopause...