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Maternal exposure to oxcarbazepine may impact the brains of offspring.

Women's Health Weekly

| May 06, 2004 | COPYRIGHT 2004 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2004 MAY 6 - (NewsRx.com & NewsRx.net) -- Maternal exposure to oxcarbazepine may impact the brains of offspring.

"Oxcarbazepine (OXC) is a widely used novel antiepileptic drug that has been available for routine prescription for 10 years. To examine low dose OXC-induced neurotoxic effects on cerebellar development, we administered 25 mg/kg OXC orally to newbom Wistar rats once a day on postnatal days 2-14. Microscopic processed cerebellar sections of the control and treated groups were examined by volumetric analysis," researchers in Turkey report.

"Volume estimations were obtained using the Cavalieri's principle using a computerized stereological image analyzer (CAST-GRID). The total volume of the cerebellum, white matter and the various cerebellar layers (except extragranular layer) were significantly increased in the treated animals," said E. Odaci and colleagues, Ondokuz Mayis University, Department of Histology and Embryology.

"These data may provide useful implications for the management of OXC-induced developmental neurotoxicity in children ...

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