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Sex hormone disturbances affect the craniofacial growth of newborn mice.

Women's Health Weekly

| May 06, 2004 | COPYRIGHT 2004 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2004 MAY 6 - (NewsRx.com & NewsRx.net) -- Sex hormone disturbances affect the craniofacial growth of newborn mice.

According to a study from Japan, "it is well-known that sex hormones influence bone metabolism. However, it remains unclear as to how sex hormones affect bone growth in newborn mice.

"In this study, we performed orchiectomy (ORX) and ovariectomy (OVX) on newborn mice and examined the effects on craniofacial growth morphometrically. ORX and OVX were performed on 5-day-old C57BL/6J mice. Four weeks after surgery lateral cephalograms were taken of all of the mice with the use of a rat and mouse cephalometer. Cephalometric analysis of the craniofacial skeleton was performed by means of a personal computer," wrote T. Fujita and colleagues, Hiroshima University, Department of Orthodontics and Craniofacial Developmental Biology.

"Inhibition of craniofacial growth was found in the experimental groups but not in the sham-operated groups. In the nasomaxillary bone and mandible the amount of growth was significantly reduced. ...

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