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Leptin is a significant regulator of bone mass.
2004 MAY 6 - (NewsRx.com & NewsRx.net) -- Leptin is a significant regulator of bone mass.
According to a study from the United States, "leptin is a powerful inhibitor of bone formation in vivo. This antiosteogenic function involves leptin binding to its receptors on ventromedial hypothalamic neurons, the autonomous nervous system and beta-adrenergic receptors on osteoblasts. However, the mechanisms whereby leptin controls the function of ventromedial hypothalamic antiosteogenic neurons remain unclear.
"In this study, we compared the ability of leptin to regulate body weight and bone mass and show that leptin antiosteogenic and anorexigenic functions are affected by similar amounts of leptin. Using a knock-in of LacZ in the leptin locus, we failed to detect any leptin synthesis in the central nervous system. However, increasing serum leptin level, even dramatically, reduced bone mass," wrote F. Elefteriou and colleagues, Baylor College of Medicine, Department of Molecular and Human Genetics.
"Conversely, reducing serum-free leptin level by overexpressing a soluble receptor for leptin increased bone mass. Congruent with these results, the high bone mass of lipodystrophic mice could be corrected by restoring serum leptin level, suggesting that leptin is an adipocyte product both necessary and ...
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- Leptin is a significant regulator of bone mass.
- Newspaper article from: Health & Medicine Week May 3, 2004 700+ words
...significant regulator of bone mass. According to a study from the United States, "leptin is a...Sciences of the United States of America (Serum...a regulator of bone mass. Proc Nat Acad...Sciences of the United States of America can...
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...enough to capture normal bone mass variability and, 3...The study found that bone mass is still increasing at...continue to accumulate bone mass into their 20s, although...at five centers in the United States: Cincinnati Children...
Source: HighBeam Research, Leptin is a significant regulator of bone mass.