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Gossypol MOA via oxidative stress, reactive oxygen species and DNA scission.
2004 MAY 6 - (NewsRx.com & NewsRx.net) -- The mechanism of action of gossypol is via oxidative stress, reactive oxygen species and DNA scission.
"Gossypol, a constituent of cottonseeds, displays various drug properties, including antifertility and anticancer. Toxicity is shown against the reproductive system, heart, liver, and membranes," researchers at San Diego State University wrote.
"The compound exhibits pro- and anti-oxidant behavior. Electron transfer (ET) functionalities, present in gossypol and its metabolites, comprise conjugated dicarbonyl, a quinone derivative, Shiff bases, and metal complexes. The parent possesses a reduction potential favorable for in vivo ET," reported P. Kovacic and colleagues.
"Considerable evidence points to oxidative stress (OS), formation of reactive oxygen species (ROS), and DNA scission, characteristics of redox cycling by ET in biosystems. Mechanistic aspects are addressed with OS-ROS-ET ...
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- Gossypol MOA via oxidative stress, reactive oxygen species and DNA scission.
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