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Steroid-linked taxol analogues cytotoxic to cancer cells in vitro.
2004 MAY 6 - (NewsRx.com & NewsRx.net) -- Steroid-linked taxol analogues cytotoxic to breast and ovarian cancer cells in vitro.
"The female steroid hormone 3,17beta-estradiol (2) was selected as an agent to target taxol (1) to estrogen receptor (ER) positive breast cancer cells. Estradiol-taxol conjugates (ETC) were synthesized through linkages from the 11- or 16-position of estradiol to the 2'-, 7-, or 10-position of taxol," wrote scientists in the Journal of Natural Products.
"All conjugates were cytotoxic to the A2870 ovarian cancer cell line, although less so than taxol. The MCF-7 breast cancer cell line (ER-alpha positive) and MDA-MB-231 breast cancer cell line (ER-a negative) were also used to evaluate the selectivity and cytotoxicity of these conjugates. One conjugate showed some selectivity for ER positive cells, but it was less potent than taxol," C.H. Liu and colleagues reported.
"Two ETC hemisuccinates were also prepared to improve the solubility of the conjugates. The corresponding Na and ...
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Source: HighBeam Research, Steroid-linked taxol analogues cytotoxic to cancer cells in vitro.