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3-D agarose matrix used to determine mechanism of cell death by COX-2 inhibitor.
2004 MAY 6 - (NewsRx.com & NewsRx.net) -- A 3-dimensional agarose matrix was used to determine the mechanism of cell death by COX-2 inhibitor etodolac.
A new method "for studying slow acting pharmaceutical COX-2 inhibitors in the MCF-7 breast cancer cell line" is described in which "cells are grown in a three-dimensional format within an agarose matrix. The cancer cells are suspended in agarose and plated in a cell culture dish, where they will form small multicellular 'tumors' in the agarose. The time frame for conducting experiments is up to 2.5 weeks," allowing "ample time for COX-2 inhibitors to induce cell death," wrote scientists at Ohio Northern University.
"Etodolac was used for these experiments, and was found to induce cell death in a time dependent manner over a 2.5-week period. This is in contrast to the cell line grown in monolayer and treated with the same concentrations of etodolac," D.H. Kinder and colleagues reported.
"This method is ...
- 3-D agarose matrix used to determine mechanism of cell death by COX-2 inhibitor.
- Newspaper article from: Biotech Week May 5, 2004 700+ words
...determine the mechanism of cell death by COX-2 inhibitor etodolac...allowing "ample time for COX-2 inhibitors to induce cell death," wrote scientists at...determining mechanisms of cell death caused by COX-2 inhibition," concluded...
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...has found increased levels of COX-2 and its product prostaglandins...pain and even infertility. COX-2 and prostaglandins are also...cancer. They reduce the rate of cell death, increase the invasiveness...Currently, drugs that inhibit COX-2 are prescribed in the treatment...
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...cell proteins they analyzed was COX-2, a physiologically important...and inflammatory processes. COX-2 has also been shown to stimulate...inhibit a type of programmed cell death called apoptosis, which helps...showed that as the level of COX-2 increases, it appears to...
Source: HighBeam Research, 3-D agarose matrix used to determine mechanism of cell death by COX-2...