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Stromal composition helps diagnosis of biphasic lesions of the breast.

Women's Health Weekly

| May 06, 2004 | COPYRIGHT 2004 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2004 MAY 6 - (NewsRx.com & NewsRx.net) -- Phyllodes tumor is a possibility when a biphasic breast tumor has cellular stroma, researchers report.

According to recent research from the United States, "Biphasic lesions of the breast are characterized by integral epithelial and stromal components. Determination of the stromal composition facilitates diagnosis."

"Lesions with predominantly specialized stroma include fibroadenoma and phyllodes tumor, and lesions with a mixture of nonspecialized and specialized stroma include fibroadenoma variant, hamartoma, and pseudoangiomatous stromal hyperplasia," wrote M.F. Lerwill and colleagues, Massachusetts General Hospital, Department of Pathology.

"Diagnostic difficulty may be encountered when a biphasic lesion has cellular stroma, raising the differential diagnosis of phyllodes tumor. Distinctive histologic features of phyllodes tumor include architectural frond formation, stromal cytological atypia, stromal mitotic ...

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