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Studies: INGN 241 enhances antitumor effects of Herceptin.
2004 MAY 6 - (NewsRx.com & NewsRx.net) -- Preclinical data presented at the 95th annual meeting of the American Association of Cancer Research demonstrate that INGN 241 enhances the antitumor effects of Herceptin (Trastuzumab) in HER2-positive breast cancer.
INGN 241, a product candidate designed to deliver the MDA-7/IL-24 gene to tumor cells, is being developed by Introgen Therapeutics, Inc., (INGN) and is in phase I and phase II clinical trials in a variety of cancers.
The data were generated in an ongoing collaboration between researchers at Introgen and the University of Texas M.D. Anderson Cancer Center.
Dr. Sunil Chada, Introgen's director of research and development, said, "These data demonstrate that enhanced cell killing of HER2-positive breast cancer cells can be achieved by combining INGN 241 with Herceptin.
"Tumor cells that overexpress HER2, a growth factor receptor that is the target of Herceptin, are more aggressive and difficult to treat than HER2-negative tumors. Herceptin has become an important treatment option for women with metastatic HER2-positive tumors, and INGN 241 appears to enhance Herceptin's antitumor effects in a model of this aggressive form of cancer. These data demonstrate the potential for INGN 241 to improve the antitumor effects of approved cancer therapies."
Abstract #5135, "Combination therapy of Ad-mda7 and Herceptin inhibits tumor growth in nude mice and increases apoptosis ...
- Studies: INGN 241 enhances antitumor effects of Herceptin.
- Newspaper article from: Cancer Weekly May 4, 2004 700+ words
...can be achieved by combining INGN 241 with Herceptin. "Tumor cells that overexpress...in cancer cell killing by INGN 241 and Herceptin as single agents or in combination...demonstrate that the combination of Herceptin and INGN 241 produced a greater antitumor...
- Introgen's INGN 241 Enhances Anti-Tumor Effects of Herceptin(R) in Preclinical...
- Press release article from: PR Newswire March 31, 2004 700+ words
...can be achieved by combining INGN 241 with Herceptin. Tumor cells that overexpress...in cancer cell killing by INGN 241 and Herceptin as single agents or in combination...demonstrate that the combination of Herceptin and INGN 241 produced a greater anti...
- Introgen's INGN 241 Shows Promise in Treatment of Breast Cancer: Effects...
- Press release article from: PR Newswire December 12, 2005 700+ words
...Tamoxifen; and with Herceptin, a biologic cancer...all settings, INGN 241 reduced cell...preclinical studies of INGN 241 as a single...combination with Herceptin were presented...chemotherapy or Herceptin when combined with INGN 241 and are consistent...
- Data Published in Surgery Demonstrate Enhanced Tumor Cell Killing When...
- Press release article from: PR Newswire August 25, 2004 700+ words
...the studies reported today, INGN 241 and Herceptin were evaluated alone or in...241. - The combination of INGN 241 and Herceptin significantly decreased the...higher in mice treated with INGN 241 and Herceptin than in animals treated with...
- Introgen's INGN 241 Gene Therapy in Combination With Herceptin(R) In Breast...
- Press release article from: PR Newswire December 18, 2001 700+ words
...the combination of INGN 241 and Herceptin(R) was evaluated...expressing Her2, INGN 241 appeared to sensitize the cancer cells to Herceptin(R), and the combined...and will be testing INGN 241 plus Herceptin(R) in other tumor...
- Introgen Therapeutics Presents Preclinical Data Supporting Utility of INGN 241...
- Press release article from: PR Newswire February 17, 2004 700+ words
...therapy for breast cancer. INGN 241 and Herceptin(R) (trastuzumab) were...combination. The data show that INGN 241 and Herceptin each reduced viability and...results from the combination of INGN 241 and Herceptin highlight the broad utility...
- Preclinical data supports utility of INGN 241 combination regimens.
- Newspaper article from: Angiogenesis Weekly March 19, 2004 700+ words
...therapy for breast cancer. INGN 241 and Herceptin (trastuzumab) were evaluated...combination. The data show that INGN 241 and Herceptin each reduced viability and...results from the combination of INGN 241 and Herceptin highlight the broad utility...
- Introgen's INGN 241 Effective Against Multiple Cancers in Preclinical Studies.
- Press release article from: PR Newswire June 6, 2005 700+ words
...Highlights of the data include: INGN 241 induces tumor-selective...These effects are enhanced when INGN 241 is combined with conventional...Bedford Laboratories) and Herceptin(R) (Genentech), or radiation...Abstract #290 suggests that INGN 241 induces apoptosis and cell...
Source: HighBeam Research, Studies: INGN 241 enhances antitumor effects of Herceptin.