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Perillyl alcohol inhibits human breast cancer cell growth in mice.
2004 MAY 6 - (NewsRx.com & NewsRx.net) -- Researchers report that monoterpene perillyl alcohol (POH) administered to nude mice inhibited breast cancer cell growth.
According to a study from Japan, "The effect of POH on cell growth, cell cycle progression, and expression of cell cycle-regulatory proteins in estrogen receptor (ER)-positive (KPL-1 and MCF-7) and ER-negative (MKL-F and MDA-MB-231) human breast cancer cell lines was examined."
"POH inhibited cell proliferation in a dose-dependent manner in all cell lines tested. POH at a dose of 500 microM had a cytostatic effect, in which growth inhibition was due to accumulation of cells in G[subscript]1-phase," wrote T. Yuri and colleagues, Kansai Medical University, Department of Pathology.
"Cell cycle progression was preceded by a decrease in G[subscript]1 cyclins (cyclin D1 and E), followed by an increase in p21 (Cip1/Waf1) and a decrease in proliferating cell nuclear antigen level. Levels of p53 and cyclin A were unchanged," the researchers wrote.
The researchers concluded: "POH at a dose of 75 mg/kg administered ...
- Perillyl alcohol suppresses breast cancer cell growth in vitro and in vivo.
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- The breast cancer-associated gene Di12 stimulates cancer cell growth.
- Newspaper article from: Genomics & Genetics Weekly September 19, 2003 700+ words
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