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2004 MAY 6 - (NewsRx.com & NewsRx.net) -- Oncoprotein HCCR-2 is related to breast cancer development and p53 tumor suppressor regulation.
"Transgenic mice containing novel oncogene HCCR-2 were generated to analyze the phenotype and to characterize the role of HCCR-2 in cellular events," investigators in South Korea wrote.
"Mice transgenic for HCCR-2 developed breast cancers and metastasis. The level of p53 in HCCR-2 transgenic mice was elevated in most tissues including breast, brain, heart, lung, liver, stomach, kidney, spleen, and lymph node." Stabilized p53 was examined for its functionality in HCCR-2 transgenic mice, reported J.S. Ko and colleagues.
"Defective induction of p53 responsive genes, including p21(WAF1), MDM2, and bax indicates that stabilized p53 in HCCR-2 transgenic mice exists in an inactive form. These results suggest that HCCR-2 represents an oncoprotein ...
Source: HighBeam Research, HCCR-2 related to breast cancer development and p53 tumor suppressor...