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HCCR-2 related to breast cancer development and p53 tumor suppressor regulation.

Women's Health Weekly

| May 06, 2004 | COPYRIGHT 2004 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2004 MAY 6 - (NewsRx.com & NewsRx.net) -- Oncoprotein HCCR-2 is related to breast cancer development and p53 tumor suppressor regulation.

"Transgenic mice containing novel oncogene HCCR-2 were generated to analyze the phenotype and to characterize the role of HCCR-2 in cellular events," investigators in South Korea wrote.

"Mice transgenic for HCCR-2 developed breast cancers and metastasis. The level of p53 in HCCR-2 transgenic mice was elevated in most tissues including breast, brain, heart, lung, liver, stomach, kidney, spleen, and lymph node." Stabilized p53 was examined for its functionality in HCCR-2 transgenic mice, reported J.S. Ko and colleagues.

"Defective induction of p53 responsive genes, including p21(WAF1), MDM2, and bax indicates that stabilized p53 in HCCR-2 transgenic mice exists in an inactive form. These results suggest that HCCR-2 represents an oncoprotein ...

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