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CXCR4 expressed in DCIS of the breast and atypical ductal hyperplasia.
2004 MAY 6 - (NewsRx.com & NewsRx.net) -- CXCR4 is expressed in DCIS of the breast and atypical ductal hyperplasia, and may play a key role in the development of these malignancies.
"Recent evidence attributed important influence to chemokines and their receptors on motility, homing, and proliferation of cancer cells at specific metastatic sites," oncologists in Austria explained.
In their study, B.C. Schmid and colleagues at the University of Vienna found that "the CXCL12 (SDF-1alpha) chemokine receptor CXCR4 is expressed in human ductal carcinoma in situ (DCIS) as well as in atypical ductal hyperplasia.
"CXCR4 was expressed in pure DCIS and DCIS with concurrent invasive disease," test results revealed. "In 66% of the samples, atypical ductal hyperplasia was present, and > 92% exhibited positive CXCR4-staining.
"Expression of CXCR4 at this very early step of tumor development indicates a role of this receptor in providing a selective advantage to such cells on their way to metastasizing carcinomas," according to the report.
"These results strengthen the ideas to target chemokine networks involved ...
- CXCR4 expressed in DCIS of the breast and atypical ductal hyperplasia.
- Newspaper article from: Immunotherapy Weekly May 5, 2004 700+ words
...DCIS of the breast and atypical ductal hyperplasia, and may play a key...DCIS) as well as in atypical ductal hyperplasia. "CXCR4 was expressed...66% of the samples, atypical ductal hyperplasia was present, and >...
- Diagnosis of atypical ductal hyperplasia still may not require excision.
- Newspaper article from: Clinical Oncology Week April 14, 2003 700+ words
...microcalcifications with atypical ductal hyperplasia is not a reason for surgery...61 (7.4%) showed atypical ductal hyperplasia (ADH). The 42 who...Clinical Pathology (Atypical ductal hyperplasia diagnosis by directional...
- Primary Bilateral Mucosa-Associated Lymphoid Tissue Lymphoma of the Breast With...
- Magazine article from: Archives of Pathology & Laboratory Medicine Gupta, Dilip Shidham, Vinod Zemba-Palko, Vlasta Keshgegian, Albert August 1, 2000 700+ words
...lymphoma with bilateral atypical ductal hyperplasia and localized amyloidosis...microscopic focus of atypical ductal hyperplasia was also observed in...amyloidosis and single focus of atypical ductal hyperplasia in both breasts. All...
- Researchers at Shandong University target hyperplasia.
- Newspaper article from: Cancer Weekly July 7, 2009 700+ words
...China, "To investigate the expression and association of ER, Ki-67 and cyclinD1 in usual ductal hyperplasia(UDH), atypical ductal hyperplasia (ADH) and ductal carcinoma in situ(DCIS) in the breast. The study included 56 cases of...
- Mammary Ductoscopy Visualizes Breast Tissue.
- Magazine article from: OB GYN News FINN, ROBERT June 1, 2001 700+ words
...findings of abnormal cells in ductal lavage. There's a continuum from normal ductal epithelium to ductal hyperplasia to atypical ductal hyperplasia, which can progress to breast cancer, Dr. Dietz said. "There is a significant percentage of...
- Scientists at Boston University report research in breast cancer.
- Newspaper article from: Blood Weekly October 22, 2009 700+ words
"Proliferative breast lesions, such as simple ductal hyperplasia (SH) and atypical ductal hyperplasia (ADH), are candidate precursors to ductal carcinoma in situ (DCIS) and invasive cancer...
- Microvessel phenotypes are altered in pre-invasive breast lesions.
- Newspaper article from: Clinical Oncology Week December 13, 2004 700+ words
...preinvasive breast lesion, unassociated with invasive carcinoma, including florid ductal hyperplasia of usual type (FDHUT, 40 cases), atypical ductal hyperplasia (ADH, 10), well-differentiated intraductal carcinoma (WDIC, 16), intermediately...
- Rigorous analysis is essential for classifying breast tissue specimens.
- Newspaper article from: Health & Medicine Week June 14, 2004 700+ words
...were boderline, including lobular neoplasia, atypical ductal hyperplasia, and columnar dell lesions with atypia. Surgical excision is recommended for atypical ductal hyperplasia, columnar cell lesions with atypia, and lobular...
