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Three key variables predict the success of intrauterine insemination.
2004 MAY 6 - (NewsRx.com & NewsRx.net) -- Three key variables predict the success of intrauterine insemination.
"This study was performed to predict pregnancy by intrauterine insemination (IUI) using computer-aided sperm analysis (CASA) estimates and strict criteria in patients with male factor infertility. IUI was performed in 682 cycles on 160 male factor infertile patients. Semen examinations were carried out by CASA and strict criteria before and after sperm preparation using continuous-step density gradient centrifugation," scientists in Japan report.
"Receiver operating characteristics (ROC) curves were constructed for assessment of the effectiveness of each individual parameter in predicting pregnancy by IUI. A clinically acceptable threshold was calculated when sensitivity plus specificity were maximum. The average cycle of IUI performed was 4.3[+ or -]2.4. Pregnancy rate per cycle and per patient were 7.2% (49/682) and 28.1% (45/160), respectively," said H. Shibahara and colleagues, Jichi Medical School, Department of Obstetrics & Gynecology.
"Using ROC curve, it was shown that normal sperm morphology assessed by the strict criteria before sperm separation and five parameters after sperm separation including rapid, progressive motility, average path velocity (VAP), curvilinear velocity (VCL), and straight line velocity (VSL) were able to predict pregnancy by IUI.
"Correlation between sperm parameters and pregnancy outcome was examined by the logistic regression model. In a multivariate analysis normal morphology before sperm separation greater than or equal to15.5% [odds ratio (OR)=2.2, p=0.02], rapid after sperm separation greater than or equal to25.5% [OR=3.9, p=0.029], and VCL after sperm separation ...
- Three key variables predict the success of intrauterine insemination.
- Newspaper article from: Health & Medicine Week May 3, 2004 700+ words
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Source: HighBeam Research, Three key variables predict the success of intrauterine insemination.