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Tolerance to morphine analgesia dependent on estrous cycle stage.
2004 MAY 6 - (NewsRx.com & NewsRx.net) -- Acute tolerance to morphine analgesia is dependent on estrous cycle stage in rats.
"Both baseline pain sensitivity and the response to antinociceptive treatment are sensitive to an animal's sex and estrous cycle stage. Sex differences are also observed in the development of antinociceptive tolerance induced by repetitive exposure to opiate drugs such as morphine. Conventional tolerance study protocols do not assess the impact of the estrous cycle stage," scientists in Russia report.
"The present study aimed to compare the development of acute tolerance to morphine-induced antinociception in male and female (cycling and ovariectomized) Wistar rats using the tail-flick test," said Elena V. Shekunova and Anton Y. Bespalov at Pavlov Medical University. "Acute tolerance was induced by two consecutive subcutaneous injections of morphine (10 mg/kg) or saline separated by an interval of 6 hours. It was found that rats pretreated with morphine were tolerant to the second morphine dose. Tolerance was most pronounced in proestrous female rats and, to a lesser degree, in male rats. It was absent in ovariectomized rats as well as during the estrus, metestrus and diestrus phases.
"Thus, ...
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Source: HighBeam Research, Tolerance to morphine analgesia dependent on estrous cycle stage.