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Osteoprotegerin and mutations on its promoter influence fracture status.
2004 MAY 6 - (NewsRx.com & NewsRx.net) -- Osteoprotegerin and mutations on its promoter influence fracture status.
According to recent research from Denmark, "the purpose of this study is to investigate the association of serum osteoprotegerin (OPG) and the A163G polymorphism in the OPG promoter with peripheral measures of bone mass and with odds ratios for wrist and hip fracture in a case-control study of postmenopausal Danish women. The study included 66 women with lower forearm fracture, 41 women with hip fracture, and 206 age-matched controls. All had broadband ultrasound attenuation (BUA) and speed of sound (SOS) measured at the heel as well as bone mineral density (BMD) measured by dual X-ray absorptiometry DXA at the distal forearm.
"Serum (S)-OPG was measured by enzyme-linked immunosorbent assay (ELISA). The A163G genotypes were determined by PCR-RFLP analysis. S-OPG levels correlated positively with age (r=0.45; p
"The G allele of the A163G was associated with significantly lower t-scores of both lower forearm BMD, heel BUA, and heel SOS as well as being significantly more frequent in the fracture patients compared to the controls. Patients with a combination of the highest quartile of S-OPG and presence of the G allele (n=23) had a significantly elevated fracture odds ratio, 4.0 (95% CI, 1.7-9.9).
"A significant negative association between S-OPG with peripheral measures of bone mass and with increased fracture odds ...
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Source: HighBeam Research, Osteoprotegerin and mutations on its promoter influence fracture...