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Studies examine role of hormones in ovarian and endometrial cancers.
2004 MAY 6 - (NewsRx.com & NewsRx.net) -- High levels of the growth factor insulin-like growth factor (IGF)-I can indicate increased risk of ovarian cancer before the age of 55, according to a study from Sweden.
Annekatrin Lukanova, conducting her dissertation research at Umea University, Sweden, wanted to examine the relationship of pre-diagnostic circulating levels of sex-steroids (androgens and estrogens), sex-hormone binding globulin (SHBG), IGF-I, IGF binding proteins (BP), and C-peptide (as a marker of pancreatic insulin secretion) with risk of developing either ovarian or endometrial cancer.
The resources of three prospective cohort studies centered in New York, in the northern part of Sweden, and in Milan, Italy, were combined to conduct two, nested, case-control studies.
The ovarian study included 132 cancer cases and 286 controls. The major finding was that elevated pre-diagnostic levels of IGF-I increased risk of developing ovarian cancer before age 55. These results parallel observations of the role of IGF-I in breast cancer and adjoin ovarian cancer to the group of common tumors in economically developed countries ...
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