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Antibodies and CD8+ T cells contribute to immunity to adenovirus vectors.
2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Neutralizing antibodies and CD8+ T lymphocytes both contribute to immunity to adenovirus serotype 5 vaccine vectors.
According to a study from the Netherlands and the United States, "The high prevalence of pre-existing immunity to adenovirus serotype 5 (Ad5) in human populations will likely limit the immunogenicity and clinical utility of recombinant Ad5 vector-based vaccines for human immunodeficiency virus type 1 and other pathogens.
"Ad5-specific neutralizing antibodies (NAbs) are thought to contribute substantially to anti-Ad5 immunity, but the potential importance of Ad5-specific T lymphocytes in this setting has not been fully characterized. Here we assess the relative contributions of Ad5-specific humoral and cellular immune responses in blunting the immunogenicity of a rAd5-Env vaccine in mice.
"Adoptive transfer of Ad5-specific NAbs resulted in a dramatic abrogation of Env-specific immune responses following immunization with rAd5-Env," reported Shawn M. Sumida and collaborators at Harvard University in the U.S. and Crucell Holland in the Netherlands. "Interestingly, adoptive transfer of Ad5-specific CD8+ T lymphocytes also resulted in a significant and durable suppression of rAd5-Env immunogenicity. These data ...
- Severe Respiratory Disease Associated with Adenovirus Serotype 14.
- Magazine article from: Internal Medicine Alert August 1, 2009 700+ words
...Respiratory Disease Associated with Adenovirus Serotype 14 Abstract and Commentary By Dean...disease associated with emergent human adenovirus serotype 14 at a US Air Force training facility...respiratory illness caused by human adenovirus serotype 14. J Infect Dis. 2009;199...
- Adenovirus serotype 35 vector has an attractive distribution profile.
- Newspaper article from: Health & Medicine Week January 5, 2004 700+ words
...NewsRx.com & NewsRx.net) -- Adenovirus serotype 35 vector has an attractive distribution profile...vitro and in vivo gene transfer proplefties of adenovirus serotype 35 vector. Mol Ther, 2003;8(5):813...
- Adenovirus serotype 35 has a broad reconstitution capacity.
- Newspaper article from: Virus Weekly May 18, 2004 700+ words
2004 MAY 18 - (NewsRx.com & NewsRx.net) -- Adenovirus serotype 35 has a broad reconstitution capacity. According to a study from Sweden, "adenovirus serotype 5 (Ad5)-based vectors can be retargeted with fiber receptor specificity...
- Adenovirus serotype 14: one of nature's pathogen cycles.(ID Consult)
- Magazine article from: Pediatric News Harrison, Christopher J. March 1, 2008 700+ words
...respiratory disease associated with emerging adenovirus serotype 14 that caused nine deaths last fall in the United...pharyngitis, and/or fever for 3-8 days. Adenovirus serotype 14 (Ad14) does appear to be a bit different...
- Acute Respiratory Disease Associated with Adenovirus Serotype 14 - Four States,...
- Magazine article from: MMWR. Morbidity and Mortality Weekly Report Anonymous November 16, 2007 700+ words
Adenovirus serotype 14 (Ad14) is a rarely reported but emerging serotype of adenovirus that can cause severe and sometimes fatal respiratory illness...
- VGX Pharmaceuticals Proprietary DNA Vaccines Delivered with Electroporation...
- Press release article from: Business Wire February 18, 2009 700+ words
...responses induced by VGX's DNA vaccines with electroporation delivery compared to those induced by the recombinant Adenovirus Serotype 5 (Ad5) vector. The data was presented at the recent 16th Conference on Retroviruses and Opportunistic Infections...
- New gene therapy findings from W.C. Adams and co-researchers published.(Report)
- Newspaper article from: Vaccine Weekly September 16, 2009 700+ words
...primary receptor for adenovirus serotype 5 (Ad5), a common...General Virology (Adenovirus serotype 5 infects human...was prepared by Vaccine Weekly editors from staff...Copyright 2009, Vaccine Weekly via NewsRx.com...
- Adenovirus antibodies quantified by luciferase transgene detection.
- Newspaper article from: Vaccine Weekly January 14, 2004 700+ words
...presence of various levels of anti-adenovirus serotype 5 (Ad5)-neutralizing antibodies...This article was prepared by Vaccine Weekly editors from staff and other reports. Copyright 2004, Vaccine Weekly via NewsRx.com & NewsRx...
Source: HighBeam Research, Antibodies and CD8+ T cells contribute to immunity to adenovirus...