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Adenoviral vectors for gene transfer and therapy reviewed.
2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Scientists review adenoviral vectors for gene transfer and therapy in a recent issue of the Journal of Gene Medicine.
"Due to the very efficient nuclear entry mechanism of adenovirus and its low pathogenicity for humans, adenovirus-based vectors have become gene delivery vehicles that are widely used for transduction of different cell types, especially for quiescent, differentiated cells, in basic research, in gene therapy applications, and in vaccine development. As an important basis for their use as gene medicine, adenoviral vectors can be produced in high titers, they can transduce cells in vivo with transgenes of more than 30 kb, and they do not integrate into the host cell genome," researchers in Germany report.
"Recent advances in the development of adenoviral vectors have brought considerable progress on issues like target cell specificity and tropism modification, long-term expression of the transgene, and have suggested that the as well as immunogenicity and toxicity in vivo, different ...
- Adenoviral vectors for gene transfer and therapy reviewed.
- Newspaper article from: Genomics & Genetics Weekly May 7, 2004 700+ words
...Scientists review adenoviral vectors for gene transfer...Journal of Gene Medicine. "Due to...their use as gene medicine, adenoviral vectors can be produced...Journal of Gene Medicine (Adenoviral vectors for gene transfer...
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...has successfully engineered novel adenoviral vectors which are capable of long term gene...these vectors described by others. Adenoviral vectors are currently being used to deliver...officer. "The ability to engineer adenoviral vectors with long term gene expression could...
- CD40-targeted adenoviral vectors show promise for tumor immunotherapy.
- Newspaper article from: Gene Therapy Weekly January 9, 2003 700+ words
...NewsRx.net) -- CD-40-targeted adenoviral vectors may be a "new vaccine modality for...situ delivery of CD40-targeted adenoviral vectors. J Immunol, 2002;169(9...Therapy, Dendritic Cell Transduction, Adenoviral Vectors. This article was prepared by Gene...
- Transgene and IntroGene Enter Into Agreement In the Field of Adenoviral Vectors.
- Press release article from: PR Newswire June 29, 2000 700+ words
...commercial production of adenoviral vectors. The agreement between...developed new generations of adenoviral vectors, with longer expression...to earlier generation adenoviral vectors, and owns a broad portfolio...
- Adenoviral vectors rely on compatible materials for transfer effectiveness.
- Newspaper article from: Medical Devices & Surgical Technology Week May 16, 2004 700+ words
...NewsRx.com & NewsRx.net) -- Adenoviral vectors rely on compatible materials for transfer effectiveness...Materials Research Part a (Biocompatibility of adenoviral vectors in poly(Vinyl chloride) tubing catheters...
- Infectivity-enhanced adenoviral vectors guide ovarian cancer gene therapy.
- Newspaper article from: Cancer Gene Therapy Week July 5, 2004 700+ words
...com & NewsRx.net) -- Infectivity-enhanced adenoviral vectors guide ovarian cancer gene therapy. "Ovarian carcinoma...Preclinical evaluation of a class of infectivity-enhanced adenoviral vectors in ovarian cancer gene therapy. Gene Therapy, 2004...
- Local delivery of adenoviral vectors encoding murine interleukin 10 induces...
- Magazine article from: Gut Lindsay, J.O. Ciesielski, C.J. Scheinin, T. Brennan, F.M. Hodgson, H.J. July 1, 2003 700+ words
...have shown previously that intravenous administration of adenoviral vectors encoding IL- 10 (AdvmuIL-10) induces hepatic IL...intravenous administration. Gene therapy strategies using adenoviral vectors encoding immunoregulatory cytokines may prove to be a...
- Ocular injection of pseudotyped adenoviral vectors could prevent blindness.
- Newspaper article from: Angiogenesis Weekly April 11, 2003 700+ words
...amp; NewsRx.net) -- Ocular injection of pseudotyped adenoviral vectors could prevent blindness. According to a study from the...ciliary body by intravitreal injection of pseudotyped adenoviral vectors. Mol Ther, 2003;7(1):27-34). The corresponding...
- Scalable production platform for oncolytic adenoviral vectors developed.
- Newspaper article from: Biotech Week July 28, 2004 700+ words
...developed a scalable production platform for oncolytic adenoviral vectors. "This study demonstrates the novel use of the HeLaS3...tumor cells: A scalable production platform for oncolytic adenoviral vectors. Biotechnol Bioeng, 2004;86(6):637-642...
- TRANSGENE Releases Additional Safety Data On the Use of Adenoviral Vectors in...
- Press release article from: PR Newswire April 5, 2000 700+ words
...our earlier clinical trials, confirm the safety of the adenoviral vectors developed by TRANSGENE," said Bernard GILLY, Chief...believe that our continuing efforts to improve the safety of adenoviral vectors and our early commitment to comply with Good Manufacturing...
Source: HighBeam Research, Adenoviral vectors for gene transfer and therapy reviewed.