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PKC delta tumor-suppressing effects mediated by p53 transcription activation.
2004 MAY 5 - (NewsRx.com & NewsRx.net) -- PKC delta tumor-suppressing effects are mediated through p53 transcription activation.
"In response to DNA damage, signal transduction pathways are activated that result in the increase of p53 protein levels, leading to either growth arrest or apoptosis. Protein kinase C (PKC) delta has been implicated as a tumor suppressor that is down-regulated by tumor-promoting phorbol esters in both mouse skin and cell culture models," wrote researchers in the Journal of Biological Chemistry.
Data indicate that the "tumor-promoting phorbol ester 12-O-tetradecanoylphorbol-13-acetate prevents DNA damage-induced up-regulation of p53 by down-regulating PKC delta. Regulation of p53 in response to stress most commonly occurs by preventing ubiquitination and degradation of the p53 protein. Surprisingly, suppression of p53 expression by inhibition of PKC delta was caused by the inhibition of p53 synthesis, not increased degradation of p53 protein," reported T. Abbas and colleagues.
"Inhibiting PKC delta blocked both basal transcription of the human p53 gene ...
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Source: HighBeam Research, PKC delta tumor-suppressing effects mediated by p53 transcription...