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Diacylated sulfoglycolipids are novel mycobacterial antigens.
2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Diacylated sulfoglycolipids are novel mycobacterial antigens stimulating CD1-restricted T cells during infection with Mycobacterium tuberculosis.
"Mycobacterial lipids comprise a heterogeneous group of molecules capable of inducing T cell responses in humans. To identify novel antigenic lipids and increase our understanding of lipid-mediated immune responses, we established a panel of T cell clones with different lipid specificities. Using this approach we characterized a novel lipid antigen belonging to the group of diacylated sulfoglycolipids purified from Mycobacterium tuberculosis," investigators in Switzerland, France, and Germany report.
"The structure of this sulfoglycolipid was identified as 2-palinitoyl or 2-stearoyl-3-hydroxyphthioceranoyl-2'-sulfate-alpha-alpha'-D-trehalose (Ac[subscript]2SGL)," stated Martine Gilleron at the Centre National de la Recherche Scientifique and collaborators in Switzerland, France, and Germany. "Its immunogenicity is dependent on the presence of the sulfate group and of the two fatty acids. Ac[subscript]2SGL is mainly presented by CD1b molecules after internalization in a cellular compartment with low pH. Ac[subscript]2SGL-specific T cells release interferon gamma, efficiently recognize M. tuberculosis-infected cells, and kill intracellular bacteria.
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Source: HighBeam Research, Diacylated sulfoglycolipids are novel mycobacterial antigens.