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Novel antigens found in Mycobacterium tuberculosis complex.
2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Two novel low-molecular-mass antigens were found specifically in the Mycobacterium tuberculosis complex.
"New tools are urgently needed for the detection of latent tuberculosis (TB). We evaluated the diagnostic potential of two novel Mycobacterium tuberculosis complex-specific candidate antigens (Rv2653 and Rv2654) and investigated T-cell recognition during natural infection in humans and experimental infection in guinea pigs. Peripheral blood mononuclear cells stimulated with peptide pools covering the full length of Rv2654 induced interferon-gamma release in 10 of 19 patients with TB," scientists in Denmark report.
"Neither Rv2654 single peptides nor Rv2654 pools were recognized by bacille Calmette-Guerin-vaccinated donors," stated Claus Aagaard and collaborators at the Statens Serum Institute and Leiden University. "However, peptides from Rv2653 were recognized by both patient groups. The cross-reactive epitopes in Rv2653 were located in a 36-amino acid stretch in the center of the molecule. Rv2654 also induced M. tuberculosis-specific skin-test responses in three of four aerosol-infected ...
- Novel antigens found in Mycobacterium tuberculosis complex.
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