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DNA vaccine against Streptococcus mutans characterized.
2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Scientists have characterized a fusion anti-caries DNA vaccine against PAc and glucosyltransferase I of Streptococcus mutans.
"Glucosyltransferases (GTFs) and A cell-surface protein (PAc) are two important virulence of the cariogenic organism Streptococcus mutans. They may mediate sucrose-in dependent or sucrose-dependent attachment of Streptococcus mutans to tooth surfaces, respectively. Thus, inhibiting both virulence factors is predicted to provide better protection against caries than inhibiting a single factor," researchers in China report.
"To develop a highly efficient vaccine against caries, we constructed a fusion DNA vaccine, pGLUA-P, by cloning the GLU region of GTF into a DNA vaccine, pCIA-P, which encodes two highly conservative regions of Pac," stated J. H. Guo and colleagues at Wuhan University. "In this report, we provide evidence that fewer caries lesions were observed in rats following subcutaneous injection of pGLUA-P, compared with pCIA-P, near the submandibular gland. Our findings suggest that a multigenic DNA vaccine may be more ...
- DNA vaccine against Streptococcus mutans characterized.
- Newspaper article from: Health & Medicine Week May 3, 2004 700+ words
...anti-caries DNA vaccine against PAc...glucosyltransferase I of Streptococcus mutans. "Glucosyltransferases...single-gene DNA vaccine." Guo and...anti-caries DNA vaccine against PAc...glucosyltransferase I of Streptococcus mutans. J Dent Res...
- Dental caries experience and salivary levels of Streptococcus mutans and...
- Magazine article from: Journal of Indian Society of Pedodontics and Preventive Dentistry Hegde, P. Kumar, B. Ashok Ankola, V. January 1, 2005 700+ words
...estimate the salivary levels of Streptococcus mutans and Lactobacilli and to study the...mean DMFT recorded was 2.41. Streptococcus mutans was detected in 87.37% and Lactobacilli...significant relation was found between Streptococcus mutans and DMFT categories ( 2 =125...
- Beyond drillings and fillings.(vaccine in development to prevent cavities...
- Magazine article from: U.S. News & World Report Fields, Helen August 11, 2003 700+ words
...Cavities are usually caused by Streptococcus mutans, one of hundreds of species of...temporarily. A vaccine would keep Streptococcus mutans from colonizing teeth in the first...immune system has kicked in but Streptococcus mutans has not yet infected most mouths...
- Streptococcus mutans epitope recognized by antibody 6-11A described.
- Newspaper article from: Biotech Week October 13, 2004 700+ words
...Scientists have characterized the Streptococcus mutans P1 epitope recognized by immunomodulatory...MAb) 6-11A directed against Streptococcus mutans surface adhesin P1 was shown previously...Immunity (Characterization of the Streptococcus mutans P1 epitope recognized by ...
- Streptococcus mutans gene product has undecaprenol kinase activity.
- Newspaper article from: Biotech Week June 18, 2003 700+ words
...com & NewsRx.net) -- A Streptococcus mutans gene product has undecaprenol kinase...previously constructed stress-sensitive Streptococcus mutans mutant Tn-1 strain resulting from...stress-responsive dgk gene from Streptococcus mutans encodes a putative undecaprenol...
- Inactivation of Streptococcus mutans gene inhibits glucan-binding protein C.
- Newspaper article from: Health & Medicine Week February 23, 2004 700+ words
...Inactivation of srtA gene of Streptococcus mutans inhibits dextran-dependent aggregation...A sortase-deficient mutant of Streptococcus mutans was prepared by insertional inactivation...Immunology (Inactivation of srtA gene of Streptococcus mutans inhibits dextran-dependent ...
- Antimicrobial activity of Rheedia brasiliensis and 7-epiclusianone against...
- Magazine article from: Phytomedicine: International Journal of Phytotherapy & Phytopharmacology Almeida, L.S.B. Murata, R.M. Yatsuda, R. Santos, M.H. Dos Nagem, T.J. Alencar, S.M. Koo, H. Rosalen, P.L. October 1, 2008 700+ words
...and its bioactive compound against Streptococcus mutans. Hexane, ethyl-acetate and ethanolic...Antimicrobial activity; 7-Epiclusianone; Streptococcus mutans Introduction Despite the advances...2003; Lemos et al., 2005). The Streptococcus mutans is an important pathogen related...
- ComX activity of Streptococcus mutans growing in biofilms reported.
- Newspaper article from: Medical Devices & Surgical Technology Week November 21, 2004 700+ words
...In many streptococci, including Streptococcus mutans, genetic competence is regulated...Microbiology Letters (ComX activity of Streptococcus mutans growing in biofilms. FEMS Microbiol...areas of Competence, Biofilm, Streptococcus mutans, Anti-Infective, Biotechnology...
