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Schistosome carbohydrates are dominant epitopes in humoral immune response.
2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Schistosome carbohydrate structures are dominant epitopes in the antiglycan humoral immune response of chimpanzees.
According to published research from Netherlands, "The development of the humoral antiglycan immune response of chimpanzees, either or not vaccinated with radiation-attenuated Schistosoma mansoni cercariae, was followed during one year after infection with S. mansoni. During the acute phase of infection both the vaccinated and the control chimpanzees produce high levels of immunoglobulin G (IgG) antibodies against carbohydrate structures that are characteristic for schistosomes carrying the Fucalpha1-3GalNAc and Fucalpha1-2Fucalpha1-3GlcNAc motifs, but not to the more widespread occurring structures GalNAcbeta1-4GlcNAc, GalNAcbeta1-4(Fucalpha1-3)GlcNAc, and Galbeta1-4(Fucalpha1-3)GlcNAc (Lewis[superscript]x).
"In addition, high levels of IgM antibodies were found against the trimeric Lewis' epitope," reported Alexandra van Remoortere at Leiden University and collaborators in the Netherlands, England, and Hungary. "Apparently, the schistosome-characteristic carbohydrate structures are dominant epitopes in the antiglycan humoral immune response of the chimpanzees. All chimpanzees showed an increase in the level of antibodies against most of the carbohydrate ...
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Source: HighBeam Research, Schistosome carbohydrates are dominant epitopes in humoral immune...