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Region of rabies virus glycoprotein plays important pathogenic role.
2004 MAY 5 - (NewsRx.com & NewsRx.net) -- A region involving amino acids 164 to 303 of the rabies virus glycoprotein plays an important role in the pathogenicity toward adult mice.
According to recent research from Japan, "The authors have previously reported that the glycoprotein of the pathogenic Nishigahara strain of rabies virus is required to lethality for adult mice. A cluster region of amino acid substitutions exists at the positions 164 to 303 on the glycoprotein between avirulent and virulent strains. In this study, the authors generated a chimeric strain having the region at the positions 164 to 303 of the glycoprotein derived from the pathogenic Nishigahara strain in the genetic background of the avirulent RC-HL strain.
"The chimeric R(G 164-303) strain restores the lethality for adult mice," reported Mutsuyo Takayama-Ito and colleagues at Gifu University. "This result clearly shows that the region at the position 164 to 303 of glycoprotein plays an important role in the lethality for adult mice. ...
- Region of rabies virus glycoprotein plays important pathogenic role.
- Newspaper article from: Health & Medicine Week May 3, 2004 700+ words
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Source: HighBeam Research, Region of rabies virus glycoprotein plays important pathogenic role.