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Metastasis-associated protein analysis indicates different metastasis roles.
2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Metastasis-associated protein analysis indicates different roles they may play in metastasis.
"Metastasis is the most insidious and life threatening aspect of cancers. However little is known about the molecular mechanisms of tumor metastasis. A poorly metastatic Acc-2 cell line and highly metastatic Acc-M cell line were selected as an experimental model to study on metastatic mechanisms and antimetastatic procedures," wrote scientists in China.
"Two-dimensional get electrophoresis and mass spectrometry were combined to approach the protein profiles associated with tumor metastasis between Acc-2 and Acc-M cell lines. Image analysis of silver stained 2-dimensional gets revealed that 12 protein spots showed significantly quantitative and qualitative variations and mass spectrometry is utilized to further identify these spots," reported J. An and colleagues.
"Of the identified proteins, transketolase, Dim1p, v-Ha-ras oncogene, type I collagen pro alpha, tumor necrosis factor (ligand) superfamily member 4, and pirin etc, have shown associations with ...
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