AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Oncogenesis from single base mutation in IRES of Epstein-Barr nuclear antigen 1.
2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Oncogenesis develops from a single base mutation in the internal ribosome entry site of Epstein-Barr nuclear antigen 1.
Recently published data show that "the U leader exon located within the 5' untranslated region of Epstein-Barr nuclear antigen 1 (EBNA1) gene contains an internal ribosome entry site (IRES) element. Sequence analysis of the U leader exon was undertaken in samples from 19 patients with infectious mononucleosis and 19 patients with lethal lymphoproliferative diseases and in 15 spontaneously established lymphoblastoid cell lines," wrote investigators in Japan.
"The sequence was conserved except for a single base substitution (T-C) at position 67,585. Although the mutation was detected in only one case of infectious mononucleosis, it was found in more than half of the lethal lymphoproliferative diseases and all lymphoblastoid cell lines," R. Endo and colleagues reported.
"The results suggest that a mutation in the RES element affects EBNA1 gene expression at the translational level ...
- Oncogenesis from single base mutation in IRES of Epstein-Barr nuclear antigen 1.
- Newspaper article from: Anti-Infectives Week May 3, 2004 700+ words
...ribosome entry site of Epstein-Barr nuclear antigen 1. Recently published data...untranslated region of Epstein-Barr nuclear antigen 1 (EBNA1) gene contains...ribosome entry site of Epstein-Barr nuclear antigen 1 mRNA. J Med Virol, 2004...
- Computerized Image Analysis of p53 and Proliferating Cell Nuclear Antigen...
- Magazine article from: Archives of Pathology & Laboratory Medicine Elhafey, Ahmed S. Papadimitriou, John C. El-Hakim, Mohamed S. El-Said, Ahmed I. Ghannam, Bahaa B. Silverberg, Steven G. July 1, 2001 700+ words
...ploidy status, proliferating cell nuclear antigen [PCNA] and Ki-67 immunoreactivity...processes.[15] Proliferating cell nuclear antigen is a 36-kd DNA polymerase delta...tonsil for PCNA. Proliferating cell nuclear antigen and p53 indexes were defined as the...
- KSHV latent nuclear antigen disruption leads to abortive episome persistence.
- Newspaper article from: Anti-Infectives Week December 27, 2004 700+ words
...associated herpesvirus latent nuclear antigen disruption leads to abortive episome persistence. "Latent nuclear antigen (LNA) is implicated in Kaposi...associated herpesvirus latent nuclear antigen leads to abortive episome persistence...
- Second P. falciparum proliferating cell nuclear antigen found.
- Newspaper article from: Proteomics Weekly February 17, 2003 700+ words
...NewsRx.net) -- "Proliferating cell nuclear antigen seems to exist as a single form in...second additional proliferating cell nuclear antigen (PfPCNA2) in Plasmodium falciparum...Identification of a second proliferating cell nuclear antigen in the human malarial pathogen Plasmodium...
- EBV-induced growth proliferation inhibited by nuclear antigen EBNA2-TAT peptide.
- Newspaper article from: Blood Weekly June 17, 2004 700+ words
...growth proliferation is inhibited by nuclear antigen EBNA2-TAT peptide. "Epstein...latency Epstein-Barr virus-encoded nuclear antigen (EBNA)2 transcriptional transactivator...induced growth proliferation by a nuclear antigen EBNA2-TAT peptide. Proc Natl Acad...
- Nuclear antigen leader protein (EBNA-LP) may also regulate apoptosis.
- Newspaper article from: Cancer Weekly March 11, 2003 700+ words
...According to a study from Japan, "Epstein-Barr virus (EBV) nuclear antigen leader protein (EBNA-LP) plays a critical role in EBV...Microbiology and Immunology (Epstein-Barr virus (EBV) nuclear antigen leader protein (EBNA-LP) forms complexes with a cellular...
- EBV nuclear antigen leader protein induces B-cell TARC expression.
- Newspaper article from: Cancer Weekly June 1, 2004 700+ words
...com & NewsRx.net) -- The Epstein-Barr virus nuclear antigen leader protein (EBNA-LP) induces TARC expression by...study in the Journal of Virology (Epstein-Barr virus nuclear antigen leader protein induces expression of thymus- and activation...
- Expression of PCNA and bcl-2 in basaloid squamous cell carcinoma of the larynx:...
- Magazine article from: Ear, Nose and Throat Journal Deniz, Kemal Yuce, Imdat Cagli, Sedat Okten, Turhan Guney, Ercihan August 1, 2008 700+ words
...immunohistochemical analysis of the expression of proliferating cell nuclear antigen (PCNA) and bcl-2 protein in 15 patients with laryngeal...treatment planning has been difficult. Proliferating cell nuclear antigen (PCNA) is a protein that exists in cell nuclei. It plays...
Source: HighBeam Research, Oncogenesis from single base mutation in IRES of Epstein-Barr nuclear...