AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Nasal Flt3 ligand cDNA elicits dendritic cells for enhanced mucosal immunity.
2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Nasal Flt3 ligand cDNA elicits CD11c+CD8+ dendritic cells for enhanced mucosal immunity.
"Nasal immunization is an effective way to induce both mucosal and systemic immune responses. In this study, we assessed a cDNA vector for Flt3 ligand (FL) for its potential to enhance mucosal immunity or tolerance. Interestingly, tolerance was avoided and elevated levels of OVA-specific antibody responses were induced in nasal washes, fecal extracts, and saliva as well as in plasma when compared with mice given nasal OVA plus DNA plasmid without the FL gene," investigators in the United States and Japan report.
"In addition, significant levels of OVA-specific CD4+ T cell proliferative responses and OVA-induced IL-4 and IL-2 production were noted in spleen and cervical lymph nodes," said Kosuke Kataoka and collaborators at the University of Alabama in the U.S. and Osaka University in Japan. "Further, marked increases in FL protein occurred in the nasal lamina propria and submandibular glands and the frequencies of CD11c+CD8+ dendritic cells (DCs) significantly increased in the mucosal tissues. Moreover, these DCs expressed high levels of CD40, CD80, CD86, and MHC class II molecules.
...
- Nasal Flt3 ligand cDNA elicits dendritic cells for enhanced mucosal immunity.
- Newspaper article from: Biotech Week May 5, 2004 700+ words
...elicits CD11c+CD8+ dendritic cells for enhanced mucosal immunity. "Nasal immunization...of CD11c+CD8+ dendritic cells (DCs) significantly...elicits CD11c+CD8+ dendritic cells for enhanced mucosal immunity. J Immunol, 2004...
- Crossing the frontlines in mucosal immunity: how natural gut flora shape host...
- Magazine article from: The Scientist Schweitzer, A. Nicola July 19, 2004 700+ words
...intestinal flora in establishing mucosal immunity, says Fioramonti, and his...retained alive in mucosal dendritic cells. These cells migrate to the...protective IFA by intestinal dendritic cells carrying commensal bact
- Adjuvant provides mucosal immunity for Chlamydia trachomatis vaccine.
- Magazine article from: Women's Health Weekly February 6, 2003 700+ words
...chemokines, such as GM-CSF, that may mobilize and mature dendritic cells and thereby enhance the induction of protective immunity...based adjuvant allows the establishment of protective mucosal immunity following vaccination with inactivated Chlamydia trachomatis...
- Dendritic cells exposed to human immunodeficiency virus type-1 transmit a...
- Newspaper article from: AIDS Weekly August 10, 1992 700+ words
...387. Superantigen-presenting dendritic cells carrying HIV virions cause an "explosive...infected with HIV. HIV-bearing blood dendritic cells could cause extensive loss of previously...lymphoid organs, where follicular dendritic cells come into contact with high numbers...
- Dendritic cells tied to psoriasis.(News)
- Magazine article from: Skin & Allergy News McNamara, Damian March 1, 2006 700+ words
...FLA. -- Recent research implicates dendritic cells in the pathogenesis of psoriasis and...promise by halting cytokines produced by dendritic cells, he noted. Psoriasis is widely known...published since 2003) suggest that dendritic cells also play a role. Researchers believe...
- IL-10-treated dendritic cells may induce GVHD risk.
- Newspaper article from: Biotech Week May 5, 2004 700+ words
...amp; NewsRx.net) -- Dendritic cells treated with interleukin...IL-10-treated immature dendritic cells in the first mixed leukocyte...were cultured with mature dendritic cells of the same origin as IL...
- FLT3 LIGAND STIMULATES GROWTH OF DENDRITIC CELLS
- Press release article from: PR Newswire November 30, 1995 700+ words
...been shown to promote the growth of dendritic cells, a formerly elusive type of cell...now, research into the utility of dendritic cells has been hampered because these cells...large numbers of functionally mature dendritic cells. "Dendritic cells could be quite...
- Scientists describe how dendritic cells grow up to take on foreign invaders.
- Newspaper article from: Proteomics Weekly March 24, 2003 700+ words
...Acting as the body's sentinels, dendritic cells are constantly on the lookout for...yet to be explained, only mature dendritic cells process and accumulate these threatening...fueled an interest in using activated dendritic cells to fight cancer and other diseases...
- Future psoriasis drugs may target role of dendritic cells.(Rx)
- Magazine article from: Internal Medicine News McNamara, Damian March 1, 2006 700+ words
...FLA. -- Recent research implicates dendritic cells in the pathogenesis of psoriasis and...promise by halting cytokines produced by dendritic cells, he noted. Psoriasis is widely known...been published since 2003) suggest dendritic cells also play a role by activating the...
- Decidual CD83+ dendritic cells implicated in some recurrent miscarriages.
- Magazine article from: Women's Health Weekly April 15, 2004 700+ words
...NewsRx.net) -- Decidual CD83+ dendritic cells may contribute to some cases of recurrent...Potent immunostimulatory (CD83) dendritic cells have recently been identified in the...sought to determine "whether decidual dendritic cells could play a role in the etiology...
Source: HighBeam Research, Nasal Flt3 ligand cDNA elicits dendritic cells for enhanced mucosal...