AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
ATRA and TSA therapy useful in acute leukemia displaying MLL-AF9 fusion gene.
2004 MAY 5 - (NewsRx.com & NewsRx.net) -- ATRA and TSA are therapeutically useful in patients with acute leukemia displaying the MLL-AF9 fusion gene.
In acute "leukemia patients with MLL (mixed linage leukemia), rearrangements tend to respond poorly to conventional therapies." The "differentiation of human myeloid leukemia cells displaying the MLL-AF9 gene" was examined "using several differentiation agents," wrote scientists from Japan.
"When MOLM-14 cells were treated with all-trans retinoic acid (ATRA) or 1beta, 25-dihydroxyvitamin D3, significant induced differentiation was observed. Trichostatin A (TSA), an inhibitor of histone deacetylase, demonstrated enhanced effects with ATRA in regard to growth inhibition and differentiation induction in MOLM-14 cells. Pretreatment with TSA before exposure to ATRA displayed increased effect," K. Iijima reported.
"Based on these findings, combined treatment with ATRA and TSA may be clinically ...
- ATRA Cites 13 'Judicial Hellholes' in New 2003 Report; Identifies Courts Where...
- Press release article from: PR Newswire November 6, 2003 700+ words
...The American Tort Reform Association (ATRA) today released Bringing Justice to Judicial...consistently applied unfairly. The result, says ATRA, is lawsuit abuse that costs consumers...favorable precedent, or both," said ATRA President Sherman Joyce. "As a result...
- Noninvasive ventilation in a pregnant patient with respiratory failure from...
- Magazine article from: Respiratory Care Bassani, Mariana A. de Oliveira, Ana Beatriz F. Neto, Antonio F. Oliveira July 1, 2009 700+ words
...pregnancies. (3) All-transretinoic acid (ATRA) is frequently used to treat acute promyelocytic...of acute myeloid leukemia), because ATRA has pro-apoptosis and cell-differentiation-induction effects. (4) ATRA has marked teratogenicity (85% of the...
- ATRA Janitorial Supply Co., Inc.(DISTRIBUTOR PROFILE)(Company Profile)
- Magazine article from: Maintenance supplies DiPaolo, Richard July 1, 2005 700+ words
...toward Pompton Plains, New Jersey, home to ATRA Janitorial Supply Company, Inc. Greeting...economic times ... and so unfolded the ATRA story. Our early morning meeting started...Anthony's brother Jason Crisafulli, ATRA's operations manager, and co-founder...
- TRISENOX(R)-ATRA Therapy Produces High Complete Remission Rates in Patients...
- Press release article from: PR Newswire December 9, 2003 700+ words
...vitamin A, all-trans retinoic acid (ATRA), that showed complete response (CR...newly diagnosed APL who were treated with ATRA (45 mg/m2) daily and TRISENOX (0...gemtuzumab in addition to the TRISENOX and ATRA combination. Eighteen patients (90 percent...
- ATRA Kicks Off 'Judicial Hellhole' Project; Tort Reform Group Seeks to Bring...
- Press release article from: PR Newswire October 2, 2002 700+ words
...The American Tort Reform Association (ATRA) today announced the kickoff of its judicial...under the law do not apply," explained ATRA President Tiger Joyce. "The project is...Vegas where they set the odds," said ATRA General Counsel Victor Schwartz. "ATRA...
- ATRA: Kerry-Edwards Victory Will Raise Tort Tax.
- Press release article from: PR Newswire July 6, 2004 700+ words
...PRNewswire/ -- The American Tort Reform Association (ATRA) today expressed serious reservations about Democratic...lawyer patrons ahead of the American people," said ATRA President Sherman Joyce. ATRA has criticized Edwards and the "Learjet lawyers...
- Tort reform total is 21 states and counting for 2003: ATRA. (Tort...
- Magazine article from: National Underwriter Property & Casualty-Risk & Benefits Management Hays, Daniel July 28, 2003 700+ words
...Tort Reform Association. According to ATRA, 2003 has been the most successful year...since 1995. The group's report comes as ATRA completed its semi-annual "Tort Reform...had already put through tort reforms, ATRA expected that Florida would pass a measure...
- ATRA Campaign Exposes Edwards' Double-Speak on Financial Support From Special...
- Press release article from: PR Newswire January 29, 2004 700+ words
...American Tort Reform Association's (ATRA) is heating up its campaign to urge John...disclose his list of major supporters. An ATRA ad appeared in The State today calling...comes from personal injury lawyers," said ATRA President Sherman Joyce. "The truth is...
Source: HighBeam Research, ATRA and TSA therapy useful in acute leukemia displaying MLL-AF9...