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CpG-A and CpG-B oligonucleotides stimulate CD8+ T-cell responses in vitro.
2004 MAY 5 - (NewsRx.com & NewsRx.net) -- CpG-A and CpG-B oligonucleotides stimulate CD8+ T-cell responses in vitro.
According to a study from Germany, "two distinct types of CpG oligodeoxynucleotide (ODN) have been identified that differ in their capacity to stimulate antigen-presenting cells: CpG-A induces high amounts of interferon-alpha (IFN-alpha) and IFN-beta in plasmacytoid dendritic cells (PDCs), whereas CpG-B induces PDC maturation and is a potent activator of B cells but stimulates only small amounts of IFN-alpha and IFN-beta. Here we examined the ability of these CpG ODNs to enhance peptide-specific CD8+ T-cell responses in human peripheral blood mononuclear cells (PBMCs)."
"The frequency of influenza matrix-specific "memory" CD8+ T cells was increased by both types of CpG ODN, whereas the frequency of Melan-A specific "naive" CD8+ T cells increased on stimulation with CpG-B but not with CpG-A," S. Rothenfusser and colleagues, University of Munich reported.
"The presence of PDCs in PBMCs was required for this CpG ODN-mediated effect. The expanded cells were cytotoxic and produced IFN-gamma on peptide restimulation. Soluble factors induced by CpG-A but not CpG-B increased the granzyme-B content and ...
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Source: HighBeam Research, CpG-A and CpG-B oligonucleotides stimulate CD8+ T-cell responses in...