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Protein from Ancylostoma ceylanicum shows promise as hookworm vaccine.
2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Recombinant Ancylostoma-secreted protein (ASP)-2 from Ancylostoma ceylanicum shows promise as a hookworm vaccine.
According to recent research published in the Journal of Infectious Diseases, "cDNAs encoding 2 Ancylostoma-secreted proteins (ASPs), Ancylostoma ceylanicum (Ay)-ASP-1 and Ay-ASP-2, were cloned from infective third-stage larvae (L3) of the hookworm A. ceylanicum and were expressed as soluble recombinant fusion proteins secreted by the yeast Pichia pastoris. The recombinant fusion proteins were purified, adjuvant formulated, and injected intramuscularly into hamsters.
"Hamsters vaccinated either by oral vaccination with irradiated L3 (irL3) or by injections of the adjuvants alone served as positive and negative controls, respectively," said Gaddam Narsa Goud and collaborators at George Washington University and the Sabin Vaccine Institute. "Anti-ASP-1 and anti-ASP-2 antibody titers exceeded 1:100,000. Each vaccinated hamster was challenged orally with 100 L3. Two groups of vaccinated hamsters (i.e., those vaccinated with either irL3 or ASP-2 formulated with Quil A) exhibited significant reductions in adult hookworm burdens, compared with control hamsters.
"The hookworms recovered from the hamsters vaccinated with ...
- Protein from Ancylostoma ceylanicum shows promise as hookworm vaccine.
- Newspaper article from: Immunotherapy Weekly May 5, 2004 700+ words
...secreted protein (ASP)-2 from Ancylostoma...shows promise as a hookworm vaccine. According to recent...secreted proteins (ASPs), Ancylostoma ceylanicum (Ay)-ASP-1 and Ay-ASP...results indicate that ASP-2 is a promising...development of a hookworm vaccine." Goud ...
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...regular intervals is cost-prohibitive, particularly for the rural poor, there has long been a demand for an anti-hookworm vaccine. With researchers in many parts of the world actively engaged in developing such a vaccine, one was finally discovered...
- Ancylostoma ceylanicum protein shows promise for hookworm vaccine.
- Newspaper article from: Drug Week June 11, 2004 700+ words
...Washington, DC 20036-2904, USA. The information in this article comes under the major subject areas of Hookworm, Hookworm Vaccine, Vaccine Development, Parasitology, Hematology, Tropical Medicine, Pediatrics, Immunology, Immunotherapy, and Proteomics...
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Source: HighBeam Research, Protein from Ancylostoma ceylanicum shows promise as hookworm vaccine.