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Novel CD4+ T-helper lymphocyte epitope identified in hepatitis A virus.
2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Researchers have identified a novel CD4+ T-helper lymphocyte epitope in the VP3 protein of the hepatitis A virus.
According to a study from Spain, "Prediction analysis of Th-cell epitopes in the VP3 capsid protein of the hepatitis A virus (HAV) revealed the occurrence of a putative Th epitope in the 102-121 region complying with all the algorithms tested. To confirm these predictions, spleen T lymphocytes obtained from BALB/c mice previously immunized with HAV, were stimulated in vitro with different concentrations of synthetic peptides 102-121 and 110-121 of VP3.
"The ability of these peptides to stimulate CD4+ T-helper lymphocytes proliferation was evaluated by an immunological flow cytometry detection of bromodeoxyuridine incorporation," said Gloria Sanchez and colleagues at the University of Barcelona. "Using this method, it is concluded that the amino terminal part of the VP3 102-121 ...
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Source: HighBeam Research, Novel CD4+ T-helper lymphocyte epitope identified in hepatitis A...