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Eurya emarginata extracts inhibit leukemia cell growth via apoptosis induction.
2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Eurya emarginata extracts inhibit leukemia cell growth via induction of apoptosis.
The "inhibitory effect of Eurya emarginata extracts on the growth of cancer cells" was examined. "The ethylacetate (EtOAc) fraction of the E. emarginata leaves markedly inhibited the growth of leukemia cells including HL-60," according to scientists in South Korea.
"When the HL-60 cells were treated with its EtOAc fraction, DNA fragmentation and sub-G1 hypodiploid cells were observed. Moreover, the EtOAc fraction of E. emarginata reduced the c-Myc and Bcl-2 protein and mRNA levels in a time-dependent manner, whereas the Bax protein and mRNA expression levels were slightly increased," S.Y. Park and colleagues reported.
Results suggest "that the inhibitory effect of E. emarginata on the growth of HL-60 appears to arise from the induction of apoptosis via the ...
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