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Surfactant protein D in the female genital tract described.
2004 MAY 5 - (NewsRx.com & NewsRx.net) -- The action of surfactant protein D in the female genital tract is described in a recent issue of Molecular Human Reproduction.
According to recent research from Denmark, "Surfactant protein D (SP-D) plays a role in innate immunity against various pathogens and in vivo studies have demonstrated that SP-D also has anti-inflammatory properties. SP-D was originally demonstrated in alveolar type II cells, but recent studies have shown extrapulmonary expression of SP-D indicating a systemic role for the protein. This study describes the presence of SP-D in the female genital tract, the placenta, and in amniotic fluid using immunohistochemistry and enzyme-linked immunosorbent assay.
"SP-D was observed in cells lining surface epithelium and secretory glands in the vagina, cervix, uterus, fallopian tubes, and ovaries," reported R. Leth-Larsen and colleagues at the University of Southern Denmark. "In the placenta, SP-D was seen in all villous and extravillous trophoblast subpopulations. Endometrial presence of SP-D in non-pregnant women varied ...
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