AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Cyclin-dependent kinase inhibitor p21 induces Flt3-ITD leukemogenesis.
2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Cyclin-dependent kinase inhibitor p21 induces Flt3-ITD leukemogenesis.
"Flt3 is a type III RTK and approximately 30% of AML patients harbor an internal tandem duplication (ITD) of the juxta-membrane region or a point mutation of the Flt3 protein leading to the constitutive activation of downstream signaling pathways and aberrant cell growth. The cyclin-dependent kinase inhibitor p21 inhibits cell growth when expressed at high levels and induces cell growth when expressed at lower levels." The "role of Flt3-ITD in the regulation of p21" was addressed in this study, wrote scientists at the Mount Sinai School of Medicine.
"Co-transfection of p21 promoter-luciferase constructs with Flt3-ITD plasmid into K562 and BaF3 cells results in the induction of p21 promoter activity and a -692/-684 STAT site is important for the induction. STAT5a binds specifically to this element and Flt3-ITD enhances the protein binding to this site. Overexpression of Flt3-ITD led to the induction of ...
- Mount Sinai School of Medicine to Receive $75 Million Gift From the Frederick...
- Press release article from: Business Wire December 2, 1999 700+ words
...Science and a Scholarship Fund Mount Sinai School of Medicine today announced the largest...to The Mount Sinai Hospital and Mount Sinai School of Medicine. "It is our hope that...not only tangible recognition of Mount Sinai School of Medicine's extraordinary achievements...
- Humanetics Corporation and Mount Sinai School of Medicine to Begin Clinical...
- Press release article from: Business Wire March 30, 2006 700+ words
...submitted to FDA for NIC5-15, Mount Sinai School of Medicine (MSSM) will proceed immediately...progression," he said. Humanetics and Mount Sinai School of Medicine Working Collaboratively...entered into two agreements with Mount Sinai School of Medicine connected to the development...
- Mount Sinai School of Medicine and EXACT Sciences Announce Publication of...
- Press release article from: Business Wire December 13, 2006 700+ words
...amp; MARLBOROUGH, Mass. -- Mount Sinai School of Medicine and EXACT Sciences Corporation...Director of Gastroenterology at Mount Sinai School of Medicine. "For those individuals...excellence in clinical care. About Mount Sinai School of Medicine Located in Manhattan, Mount...
- Brookhaven Lab, Mount Sinai School of Medicine Form Joint Center for...
- News wire article from: AScribe Health News Service April 5, 2006 700+ words
...Brookhaven National Laboratory and the Mount Sinai School of Medicine (MSSM) have signed an...Academic and Scientific Affairs for Mount Sinai School of Medicine and Senior Vice President...awarded to and administered by Mount Sinai School of Medicine. Located in Manhattan...
- Mount Sinai School of Medicine and Medisyn Technologies Announce Agreement to...
- Press release article from: Business Wire September 13, 2007 700+ words
...NEW YORK & MINNEAPOLIS -- Mount Sinai School of Medicine (MSSM) and Medisyn Technologies...candidates for treating AD." About Mount Sinai School of Medicine The Mount Sinai Medical...encompasses The Mount Sinai Hospital and Mount Sinai School of Medicine. The Mount Sinai ...
- Science from Mount Sinai School of Medicine: Using DNA to Identify Counterfeit...
- News wire article from: Ascribe Higher Education News Service November 12, 2001 700+ words
Byline: Mount Sinai School of Medicine NEW YORK, Nov. 12...apparel alone. Scientists at Mount Sinai School of Medicine have patented a technique...technique is being marketed by Mount Sinai School of Medicine, which is currently...
- Linguagen Corp. and Mount Sinai School of Medicine Complete Agreement for Basic...
- Press release article from: PR Newswire June 6, 2002 700+ words
...announced an agreement with the Mount Sinai School of Medicine (MSSM) to acquire exclusive...Institute at New York University's Mount Sinai School of Medicine. Dr. Margolskee is also...excessive sugar and excessive sodium. Mount Sinai School of Medicine is internationally ...
- Provectus Pharmaceuticals Selects Mount Sinai School of Medicine as 2nd...
- Newspaper article from: Wireless News August 24, 2009 700+ words
...Provectus Pharmaceuticals Selects Mount Sinai School of Medicine as 2nd Clinical Trial Site...biopharmaceutical company, has added Mount Sinai School of Medicine as its second and final...a dermatological therapy, and Mount Sinai School of Medicine's outstanding reputation...
