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Thyroglobulin polymorphic variation increases non-medullary thyroid cancer risk.
2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Polymorphic variation in thyroglobulin increases risk for non-medullary thyroid cancer.
"Benign thyroid disorders are strong risk factors for non-medullary thyroid cancer (NMTC). Germline variation in Tg (thyroglobulin) and TSHR (thyroid stimulating hormone receptor) confers an increased risk of benign thyroid disorders. To explore the hypothesis that polymorphic variation in these genes affects the risk of NMTC," the "frequency of TgQ2511R, TSHR-P52T and TSHR-D727E genotypes" was compared "in two series of NMTC cases and controls (group 1, Canadian 102 cases and 102 controls; group 2, British 202 cases and 298 controls)," wrote scientists in England.
"No significant association was seen with TSHR-P52T and TSHR-D727E genotypes and risk of NMTC. However, the frequency of the R-allele of TgQ2511R was over represented in NMTC cases in both study populations. The odds ratios associated with hetero- and homozygosity for the R-allele were 1.6 (95% confidence interval, 1.1-2.5) and 2.0 (95% confidence interval, 1.2-3.3), ...
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Source: HighBeam Research, Thyroglobulin polymorphic variation increases non-medullary thyroid...