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6-Nitro-7-hdroxycoumarin novel therapeutic agent for renal cell carcinoma.
2004 MAY 5 - (NewsRx.com & NewsRx.net) -- 6-Nitro-7-hdroxycoumarin may be a novel therapeutic agent for renal cell carcinoma.
"Previously, 7-hydroxycoumarin (7-OHC) and 6-nitro-7-hydroxycoumarin (6-NO2-7-OHC) have been shown to be potent and selective anti-proliferative agents to the human renal cell carcinoma (RCC) cell line, A-498. Their effect on mitogen-activated protein kinases (MAPK's) was investigated," wrote investigators in Ireland.
"6-NO2-7-OHC was shown to alter the phosphorylation status of ERK1/ERK2, p38 and SAPK, while 7-OHC activated ERK1/ERK2 but had no effect on p38 and SAPK Also, 7-OHC inhibited topoisomerase 11 mediated relaxation of DNA, while neither compound was a substrate for P-glycoprotein (P-gp) mediated multi-drug resistance (MDR)," scientists in Ireland report," reported G.J. Finn and colleagues.
"Therefore, 6-NO2-7-OHC, rather than 7-OHC, modulated signalling events associated with cellular differentiation and apoptosis, suggesting its mechanism of action may be the promotion of cellular maturation ...
- OHC LLC Recognized as Top 50 Fastest Growing Private Company in Atlanta; OHC...
- Press release article from: Business Wire April 19, 2006 700+ words
NORCROSS, Ga. -- OHC LLC, the parent company of Optimus Solutions...companies in the metro Atlanta region. This is OHC's sixth consecutive appearance on the...ranked by growth in revenues and employees. OHC grew from $124 million in revenues and...
- Pushrods have place despite rise of OHC.(Auto Weekend)
- Newspaper article from: The Washington Times Peters, Eric January 10, 1997 700+ words
...supposedly more efficient overhead cam (OHC) design. But pushrod engines have proven...output as good or better than any "modern" OHC engine on the market, it's tough to sneer at the "old fashioned" Corvette V-8. OHC engines do have their merits, though...
- Asprinio Joins OHC Environmental Engineering As Director Of Business...
- Magazine article from: Dixie Contractor December 6, 2004 700+ words
...Staff Carl J. Asprinio has recently joined OHC Environmental Engineering as director of...project opportunities and direction for OHC's sales and business development activities...active participant in trade associations. OHC Environmental Engineering's corporate...
- OHC public hearing is March 29.
- Newspaper article from: Benton County Daily Record March 8, 2006 700+ words
...Concern will hold a public hearing to update the community's needs assessment from 10 a.m. to 11 a.m. March 29 at the OHC headquarters building, 506 E Spruce St. in Rogers. (Benton County Daily Record) To read the full text of this article...
- Triad OHC engines.
- Magazine article from: Outdoor Power Equipment September 1, 2000 700+ words
...Kohler expanded its national award-winning overhead camshaft line with 2 models: the air-cooled, 20- and 23-hp. Triad OHC engines. These V-twin, horizontal-shaft engines offer the same user benefits as the original 16- and 18-hp. models...
- Small OHC engines.(Engines, Drivetrains & Components)
- Magazine article from: OEM Off-Highway April 1, 2006 700+ words
Subaru Robin's EX Series gasoline engines use chain-driven overhead cam (OHC) technology. [ILLUSTRATION OMITTED] * Four models ranging from 4.5 to 9 hp * Pent-roof-type combustion chamber for high...
- OHC engines. (Product News).
- Magazine article from: Designfax December 1, 2002 700+ words
The EX Series of air-cooled gasoline industrial engines features a chain-drive overhead cam that reduces noise by 2 dBA, as well as reduces the force needed to start the engine by as much as 30 to 40%. A pent-roof combustion chamber, combined with improved intake and exhaust ports, increases
- Mass. OHC has new scholarship program. (Dateline).(Massachusetts Oilheat...
- Magazine article from: Fuel Oil News April 1, 2002 700+ words
The Massachusetts Oilheat Council (MOC) is introducing an ambitious vocational training scholarship program for both residents in the state who would like employment as an oilheat technician and for companies who wish to sponsor current or new employees for training. Fifty full-tuition scholarships
Source: HighBeam Research, 6-Nitro-7-hdroxycoumarin novel therapeutic agent for renal cell...