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RNA-transfected cells induce responses against viral and tumor antigens.
2004 MAY 5 - (NewsRx.com & NewsRx.net) -- RNA-transfected CD40-activated B cells induce functional T-cell responses against viral and tumor antigen targets.
"Vaccination with antigen-presenting cells (APCs) engineered to mimic mechanisms of immune stimulation represents a promising approach for cancer immunotherapy. Dendritic cell vaccines have entered phase 3 testing in adult malignancies, but such vaccines in children have been limited. We demonstrate that CD40-activated B cells (CD40-B) transfected with RNA may serve as an alternative vaccine that can be generated from small blood volumes regardless of patient age," scientists writing in the journal Blood report.
"CD40-B from pediatric patients are efficient APCs and can be loaded with RNA as an antigenic payload, permitting simultaneous targeting of multiple antigenic epitopes without the necessity of HLA matching," stated Christina M. Coughlin and colleagues at the University of Pennsylvania. "For viral and tumor antigens, CD40-B/RNA technology induced cytotoxic T lymphocytes (CTLs) from adults and children, which could be identified with peptide/major histocompatibility complex (MHC) tetramers. These CTLs secreted interferon-gamma (IFN-gamma) and killed targets in an MHC-restricted fashion. For pooled neuroblastoma RNA and autologous ...
- Dendritic cells induce antitumor CD8 cells in chronic lymphocytic leukemia.
- Newspaper article from: Vaccine Weekly March 26, 2003 700+ words
...The information in this article comes under the major subject areas of Cancer Vaccine, Dendritic Cell Vaccine, Leukemia Therapy, and Vaccine Development. This article was prepared by Vaccine Weekly editors from staff and other reports.
- Endothelial cells induce T-cell chemokine CCL21 in autoimmune patients.
- Newspaper article from: Immunotherapy Weekly April 2, 2003 700+ words
2003 APR 2 - (NewsRx.com & NewsRx.net) -- Endothelial cells induce T-cell chemokine CCL21 in autoimmune patients. "The signals that mediate T-cell infiltration during T-cell autoimmune diseases...
- Conditional TRAIL-expressing T cells induce apoptosis in B-cell lymphomas.
- Newspaper article from: Cancer Weekly February 17, 2004 700+ words
2004 FEB 17 - (NewsRx.com & NewsRx.net) -- Conditional TRAIL-expressing T cells induce apoptosis in B-cell lymphomas. According to researchers from Germany, "in the present study, we demonstrate the utility of...
- AIDS-KS derived cultured spindle cells induce vascular hyper permeability which...
- Newspaper article from: AIDS Weekly Nakamura, S. Sakurada, S. Weich, H.A. Rasheed, S. Salahuddin, S.Z. December 21, 1992 700+ words
...AIDS-KS derived long-term cultured spindle shaped cells (AIDS-KS Cells). We have previously reported that these cells induce KS like lesions in nude mice. We report here that metabolically active AIDS-KS cells also induce biphasic vascular hyper...
- AIDS-KS derived cultured spindle cells induce vascular hyper-permeability which...
- Newspaper article from: Cancer Weekly Nakamura, S. Sakurada, S. Weich, H.A. Rasheed, S. Salahuddin, S.Z. December 14, 1992 700+ words
...AIDS-KS derived long-term cultured spindle shaped cells (AIDS-KS Cells). We have previously reported that these cells induce KS like lesions in nude mice. We report here that metabolically active AIDS-KS cells also induce biphasic vascular hyper...
- Patients' dendritic cells induce fewer virus-specific T helper cells.
- Newspaper article from: Immunotherapy Weekly December 4, 2002 700+ words
2002 DEC 4 - (NewsRx.com & NewsRx.net) -- Weak antiviral immune responses observed in patients with chronic hepatitis B virus infection may partly be due to insufficient T-cell stimulating capacities of dendritic cells, say researchers in Germany. "Insufficient stimulatory capacities of
- Patients' dendritic cells induce fewer virus-specific T helper cells.(Brief...
- Newspaper article from: Virus Weekly December 3, 2002 700+ words
2002 DEC 3 - (NewsRx.com & NewsRx.net) -- Weak antiviral immune responses observed in patients with chronic hepatitis B virus infection may partly be due to insufficient T-cell stimulating capacities of dendritic cells, say researchers in Germany. "Insufficient stimulatory capacities of
- Cytokines from activated T cells induce normal endothelial cells to acquire the...
- Newspaper article from: AIDS Weekly Fiorelli, V. Gendelma, R. Samaniego, F. Markham, P.D. Ensoli, B. May 22, 1995 700+ words
According to the authors' abstract of an article published in Journal of Clinical Investigation, "Kaposi's sarcoma (KS) is a proliferative disease of vascular origin particularly frequent in HIV-1-infected homosexual men (AIDS-KS) and characterized by proliferating spindle-shaped cells,
- Geron announces publication of studies showing oligodendrocyte progenitors...
- News wire article from: Asia Africa Intelligence Wire May 11, 2005 700+ words
(From Chemical Business NewsBase - Press Release) Geron Corp announced the publication of studies showing that oligodendrocyte progenitors, differentiated from human embryonic stem cells (hESCs), produce functional improvements in rats with spinal cord injuries. In the 11 May 2005 issue of the
- Geron Announces Publication of Studies Showing Oligodendrocyte Progenitors...
- Press release article from: Business Wire May 11, 2005 700+ words
MENLO PARK, Calif. -- Geron Corporation (Nasdaq:GERN) announced today the publication of studies showing that oligodendrocyte progenitors, differentiated from human embryonic stem cells (hESCs), produce functional improvements in rats with spinal cord injuries. These studies provide proof of
Source: HighBeam Research, RNA-transfected cells induce responses against viral and tumor...