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P-glycoprotein-derived peptides inhibited multidrug resistance of tumors.
2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Immunization with synthetic P-glycoprotein-derived peptides inhibited multidrug resistance of tumors.
"Overexpression of the membrane glycoprotein (P170) represents the most common multidrug resistance (MDR) mechanism in cancer therapy. Specific auto-antibodies to extracellular loops 1, 2, and 4 of murine P170 were elicited in mice using palmitoylated synthetic peptides reconstituted in liposomes, with or without Lipid A, and resuspended in alum. IgM antibodies were detected 14 days following the first injection and IgG1 became predominant after the third challenge," scientists writing in the European Journal of Cancer report.
"Animals did not show any autoimmune symptoms or induced toxicity up to 18 months after the immunization," said C. Pawlak-Roblin at the UFR Pharmacie and collaborators in France and Switzerland. "Previous immunizations of mice using liposomes with MDR1 peptides increase the efficacy of chemotherapy treatments with doxorubicin and vinblastine against P388 R cells with increase of 77% in the survival half time in the immunized group. Sera from the ...
- P-glycoprotein-derived peptides inhibited multidrug resistance of tumors.
- Newspaper article from: Drug Week May 7, 2004 700+ words
...most common multidrug resistance (MDR) mechanism...writing in the European Journal of Cancer...study in the European Journal of Cancer (Inhibition of multidrug resistance by immunisation...publisher of the European Journal of Cancer...
- VERTEX PHARMACEUTICALS EXPANDS CLINICAL PROGRAM IN CANCER MULTIDRUG RESISTANCE
- Press release article from: PR Newswire February 8, 1995 700+ words
...patients with cancer complicated by multidrug resistance. The study, which will test VX...Bethesda, MD, titled "Overcoming the Multidrug Resistance Challenge: Mechanisms, Strategies...one of the most common forms of multidrug resistance. In addition, in vivo studies...
- Vertex Pharmaceuticals and BioChem Pharma Begin Phase II Trial of Multidrug...
- Press release article from: PR Newswire September 11, 1997 700+ words
...cancer. Vertex is developing Incel multidrug resistance inhibitor to resensitize tumor cells...patients with cancer complicated by multidrug resistance. BioChem is Vertex's partner...marketing of Incel in Canada. Incel multidrug resistance inhibitor is currently in Phase...
- Multidrug resistance ATP-binding cassette transporters reviewed.
- Newspaper article from: Pharma Business Week January 26, 2004 700+ words
...net) -- A scientists reviews multidrug resistance ATP-binding cassette transporters...from the United States, "Clinical multidrug resistance is caused by a group of integral...class of these permeases, known as multidrug resistance ATP-binding cassette (ABC) transporters...
- P-glycoprotein-mediated multidrug resistance can be blocked by ginsenoside Rg3.
- Newspaper article from: Cancer Gene Therapy Week March 10, 2003 700+ words
...glycoprotein-mediated multidrug resistance can be blocked by ginsenoside...from South Korea, "Multidrug resistance has been a major problem...neither repression of multidrug resistance gene expression nor...
- P-glycoprotein mediates multidrug resistance in malignant glioma cell lines.
- Newspaper article from: Health & Medicine Week January 19, 2004 700+ words
...P-glycoprotein and multidrug resistance-associated protein mediate specific patterns of multidrug resistance in malignant glioma cell lines...Understanding and overcoming multidrug resistance (MDR) may be a promising...
- Multidrug-resistance-associated protein inhibitors synthesized.
- Newspaper article from: Anti-Infectives Week April 26, 2004 700+ words
...pyrrolopyrimidine as selective multidrug-resistance-associated protein inhibitors in multidrug resistance. According to recent research...pyrrolopyrimidine as selective multidrug-resistance-associated protein inhibitors...
- New Multidrug Resistance Assay Kit Launched.
- Newspaper article from: Biotech Week August 22, 2001 700+ words
...announced the launch of the FLIPR(R) Multidrug Resistance Assay Kit, its first reagent product...drug-discovery market. The FLIPR Multidrug Resistance Assay Kit provides a simple, high...method for screening compounds for multidrug resistance (MDR) pump activity. MDR is important...
