AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Phase I healthy volunteer trial of HYB2055 completed.
2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Hybridon, Inc., (HBY) has completed a phase I trial of HYB2055 in healthy volunteer subjects.
In this trial, this drug candidate was safe and biologically active. HYB2055 is a second-generation immunomodulatory oligonucleotide (IMO) that combines a novel DNA structure, referred to as an Immunomer, and a synthetic CpR immunomodulatory motif.
"HYB2055 has exhibited an excellent safety profile over the 32-fold range of dosages evaluated in this phase I trial," said R. Russell Martin, MD, senior vice president of drug development at Hybridon. "Evidence of biological activity by several parameters was seen at all dose levels administered and we have already progressed to higher dosages in a separate, on-going phase I trial in oncology patients."
"Hybridon is developing HYB2055 as IMOxine for oncology applications and Amplivax as a lower dosage product for vaccine adjuvant use," added Stephen R. Seiler, Hybridon's CEO. "Initial results of our phase I cancer trial of IMOxine also have been encouraging. We expect to complete that trial and initiate a phase II trial in cancer patients later this year. The first phase I trial of Amplivax is anticipated to begin in the second quarter of 2004."
Hybridon presented a poster entitled "Immunological Activity of HYB2055, a TLR9 Agonist, in Healthy Volunteers" at the American Association for Cancer Research meeting. An earlier presentation at another meeting had described the safety results of the volunteer trial.
Twenty-eight males aged 18-45 years were ...
- SARS vaccine phase I clinical testing commences.
- Newspaper article from: Vaccine Weekly March 3, 2004 700+ words
...deadly virus. The first phase of human testing will...Organization, and the SFDA. If phase I testing is successful, then the second phase of clinical testing will...Investigational New Drug; clinical phases I, II, and III; New...article was prepared by Vaccine Weekly editors from ...
- ASCO accepts BLP25 liposomal vaccine phase IIB trial results for presentation.
- Newspaper article from: Vaccine Weekly April 21, 2004 700+ words
...announced results from its phase II study of L-BLP25 in a...ASCO involves the Theratope phase III study. The poster will...reported in June 2003 that the phase III results showed that Theratope...This article was prepared by Vaccine Weekly editors from staff and other...
- Anthrax vaccine phase II trial begins.
- Newspaper article from: Vaccine Weekly May 12, 2004 700+ words
...sector collaboration." The phase II study will evaluate the...VaxGen plans to conduct a second phase II trial of rPA102 later this...period. VaxGen launched a phase I trial of rPA102 in the second...This article was prepared by Vaccine Weekly editors from staff and other...
- Positive results reported from phase IIb BLP25 liposomal vaccine trial.
- Newspaper article from: Vaccine Weekly April 28, 2004 700+ words
...randomized, open-label phase IIb trial of BLP25 liposomal...used in planning the next phase of clinical development...This article was prepared by Vaccine Weekly editors from staff and other reports. Copyright 2004, Vaccine Weekly via NewsRx.com & NewsRx...
- First stage of phase 2 study for non-small cell lung cancer completed.
- Newspaper article from: Vaccine Weekly December 29, 2004 700+ words
...with that reported in previous phase 1 studies. The trial is an...decisions in our two on-going phase 2 metastatic melanoma studies...of 2005 and our on-going phase 2 chronic lymphocytic leukemia...This article was prepared by Vaccine Weekly editors from staff and other...
- Vaccine genes of P. falciparum during hepatic phase identified.
- Newspaper article from: Vaccine Weekly June 2, 2004 700+ words
...are transcribed during this phase," scientists writing in the...transcribed during the hepatic phase may be of interest with respect...falciparum during the hepatic phase of its life cycle. Parasitol...This article was prepared by Vaccine Weekly editors from staff and other...
- Assays with extended incubation phases needed to monitor HIV vaccine trials.
- Newspaper article from: Vaccine Weekly April 21, 2004 700+ words
...with extended incubation phases. According to published...vaccination strategy of a phase I clinical trial were...with extended incubation phases to monitor current HIV...with extended incubation phases. Vaccine, 2003;22...article was prepared by Vaccine Weekly editors from staff ...
- NIH supports phase I clinical trial of DNA-based anthrax vaccine.
- Newspaper article from: Vaccine Weekly June 30, 2004 700+ words
...the company it will support a phase I clinical trial of the company...research hospitals that conduct phase I and phase II clinical trials for NIAID...This article was prepared by Vaccine Weekly editors from staff and other reports...
- Phase II colorectal trial results for Theratope vaccine to be presented at...
- Newspaper article from: Vaccine Weekly April 16, 2003 700+ words
...countries in March 2001. This phase III trial is a double-blinded...to the 1,030 women in the phase III trial, more than 400 patients...with Theratope, mostly in phase II trials. The ASCO Annual...This article was prepared by Vaccine Weekly editors from staff and other...
- Vaccine candidate for precancerous cervical lesions in new phase 2 trial.
- Newspaper article from: Vaccine Weekly December 29, 2004 700+ words
...that it is conducting a new phase 2 clinical trial with its vaccine...obtained from the previous phase 2 trial that was conducted...immune response. The first phase 2 trial included 31 patients...This article was prepared by Vaccine Weekly editors from staff and other...
Source: HighBeam Research, Phase I healthy volunteer trial of HYB2055 completed.