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Pasteurella multocida contains multiple hemoglobin-binding proteins.

Vaccine Weekly

| May 05, 2004 | COPYRIGHT 2004 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Pasteurella multocida contains multiple immunogenic hemin- and hemoglobin-binding proteins.

According to a study from Spain, "Iron-dependent outer membrane proteins (IROMPs) play an important role in bacterial pathogenesis and present several attributes of potential vaccine candidates. TBLASTN analysis of the Pasteurella multocida Pm70 genome using the same molecules of other bacterial pathogens as a query identified eight putative hemin and hemoglobin receptors for this organism. Quantitative binding assays have demonstrated that the proteins PM0040, PM0236, PM0741, PM1081, PM1428, PM0592, and HgbA bind both hemin and hemoglobin, whereas PM0576 and PM1282 ORFs only bind either hemoglobin or hemin, respectively.

"Furthermore, Western blot analysis showed that P. multocida-infected mice generate specific antibodies against PM0040, PM0236, PM0741, PM1081, PM1428, PM0592, and HgbA proteins," reported Montserrat Bosch and colleagues at the Universitat ...

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Source: HighBeam Research, Pasteurella multocida contains multiple hemoglobin-binding proteins.

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