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EGCG inhibits radiation-induced apoptosis by inactivating capase pathway.
2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Polyphenol EGCG inhibits radiation-induced apoptosis by inactivating the capase pathway in HaCaT cells.
"Green tea is a rich source of polyphenols, and (-)-epigallocatechin-3-gallate (EGCG) is a major constituent of green tea polyphenols." The "effect of EGCG on apoptosis induced by irradiation" was investigated in the "keratinocytic cell line HaCaT. Irradiation by gamma-ray induced apoptosis with concomitant cleavage of caspase-3 and its in vivo substrate poly(ADP-ribose) polymerase," scientists in Japan wrote.
"Treatment of cells with EGCG inhibited irradiation-induced apoptosis as detected by Hoechst staining and internucleosomal cleavage of DNA, and prevented the cleavage of these proteins by irradiation. We also found that the treatment of cells with EGCG alone suppressed cell growth and induced apoptosis in these cells," reported H. Kondo and colleagues.
"Our results suggest that EGCG inhibits irradiation-induced apoptosis by inactivating the caspase pathway in HaCaT cells. ...
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Source: HighBeam Research, EGCG inhibits radiation-induced apoptosis by inactivating capase...