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Current concepts and future prospects for Alzheimer disease vaccines.
2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Researchers review current concepts and future prospects for Alzheimer disease vaccines in a recent issue of the journal Alzheimer Disease and Associated Disorders.
"Alzheimer disease (AD) is the most prevalent form of dementia worldwide and is characterized by the progressive accumulation of the 42-residue amyloid beta protein (A-beta) in brain regions serving memory and cognition. Only a few years ago, the proposition that AD may be amenable to any kind of therapy would have met with considerable skepticism. Yet, recent, exciting developments appear to suggest that immunizing against A-beta may bear some potential for arresting or even curing AD," investigators in Switzerland, the United States, and Canada report.
"However, a clinical trial of vaccination with synthetic human A-beta in AD patients was halted because of the development of meningoencephalitis in some patients," said Frank L. Heppner at the Institute of Neuropathology in Switzerland and collaborators in the U.S. and Canada. "Further studies aimed at elucidating the mechanism of A-beta clearance ...
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...its drug PBT-1 (clioquinol) for Alzheimer Disease slowed progression of cognitive decline...lowering in plasma of the key marker of Alzheimer disease, the amyloid beta protein. Treatment...reasoning using a cognitive score on the Alzheimer disease Assessment Scale, the so-called...
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...can provide earlier diagnosis of Alzheimer disease and distinguish it from other types...that is a strong early predictor of Alzheimer disease. People with mild cognitive impairment...cognitive impairment progress to Alzheimer disease while others do not. Being able...
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...study of dapsone for treatment of Alzheimer disease conducted over 52 weeks with 201...of dapsone on the progression of Alzheimer disease was not statistically significant...patients with mild-to-moderate Alzheimer Disease (AD). The primary endpoint for...
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Introduction Alzheimer disease, the most common cause of dementia...early and accurate diagnosis of Alzheimer disease is warranted, especially since...fluid (CSF) of patients with Alzheimer disease are a well established finding...
Source: HighBeam Research, Current concepts and future prospects for Alzheimer disease vaccines.