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Modified RESA protein peptide 6671 induces protection against malaria.
2004 MAY 5 - (NewsRx.com & NewsRx.net) -- Modifying RESA protein peptide 6671 to fit into HLA-DRbeta[subscript]1 pockets induces protection against malaria.
According to a study from Colombia, "6671 is a non-immunogenic, conserved high activity red blood cell binding peptide located between residues 141 and 160 of the Plasmodium falciparum RESA protein. This peptide's critical red blood cell (RBC) binding residues have been replaced by amino acids having similar mass but different charge to change their immunologic properties. Three analogues (two of them immunogenic and protective and one immunogenic) were studied by purified HLA-DRbeta[subscript]1* binding and NMR to correlate their structure with their immunological properties.
"Native peptide 6671 had a very flexible beta-sheet structure, while its immunogenic, protective, and non-protective peptide analogues presented an alpha-helical structure having different locations and lengths," reported Martha Patricia Alba and colleagues at the Fundacion Instituto de Inmunologia de Colombia (FIDIC) in Bogota. "These changes in peptide structure facilitated their fitting into HLA-DRbeta[subscript]1* molecules. This paper shows for the first time how modifications ...
- Modified RESA protein peptide 6671 induces protection against malaria.
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