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DNA vaccines encoding ras epitopes and B7.1 reduced tumor burden in rats.
2004 MAY 5 - (NewsRx.com & NewsRx.net) -- DNA vaccines encoding mutated ras epitopes and the costimulatory molecule B7.1 reduced adenocarcinoma tumor burden in rats.
"1-Methyl-1-nitrosourea (MNU), a well characterized carcinogen, was used to induce adenocarcinomas in rat mammary gland. One hundred fifty days after the first injection of MNU, the animals were treated with DNA minigene vaccines encoding ras T cell epitopes together with the co-stimulatory molecule B7.1 (CD 80)," scientists in Slovakia report.
"Five injections with a biolistic device (gene gun) in monthly intervals significantly reduced the tumor burden," said Sven Mostbock and collaborators at the Slovak Academy of Sciences and the University of Salzburg in Austria. "A therapeutic effect could be measured with both, DNA vaccines encoding ras epitopes and B7.1, as well as with a DNA vaccine expressing solely the B7.1 molecule thus indicating the potential of genetic vaccination for tumor treatment."
Mostbock and his coauthors published their study in ...
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Source: HighBeam Research, DNA vaccines encoding ras epitopes and B7.1 reduced tumor burden in...