Determinants of HIV disease progression: six-year longitudinal study in the Edinburgh haemophilia cohort. (Weekly Periodical Report)

SOURCE: The Lancet, November 9, 1991;338(8776):1159-1163.

Individuals who progress rapidly to AIDS can be identified by measures of immune function prior to HIV exposure and early in the course of infection, study of a unique cohort indicates.

University of Edinburgh researcher Peter Simmonds and colleagues began study

of a group of hemophiliacs prior to their infection with HIV-1 and followed these subjects since their seroconversion. These studies indicate that the rate of HIV disease progression is related to total plasma IgM concentration prior to infection, the pattern of HIV-specific IgM and IgA responses near the time of IgG seroconversion, concentrations of plasma interleukin-2 receptor, and …