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Signs of cerebral amyloid angiopathy-related inflammation reported.
2004 APR 21 - (NewsRx.com & NewsRx.net) -- Researchers report the clinical manifestations of cerebral amyloid angiopathy-related inflammation in a recent issue of the Annals of Neurology.
According to published research from the United States, "To explore the clinical effects of inflammation associated with vascular deposits of the amyloid beta peptide (A-beta), we analyzed 42 consecutive patients with pathologically diagnosed cerebral amyloid angiopathy (CAA) for evidence of an inflammatory response. Inflammation with giant-cell reaction surrounding amyloid-laden vessels was identified in 7 of the 42 cases."
"The clinical symptoms in each of the seven were subacute cognitive decline or seizure rather than hemorrhagic stroke, the primary clinical presentation in 33 of 35 patients with noninflammatory CAA (p
"Of the six inflammatory CAA patients with available follow-up information, five demonstrated clinical and radiographic improvement after immunosuppressive treatment," said Eng and her coauthors. "The syndrome of CAA-related perivascular inflammation appears to represent a subset of CAA with clinically distinct symptoms that may respond to immunosuppressive treatment. These data add to evidence that inflammation against A-beta can cause vascular dysfunction, a potential mechanism for the ...
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Source: HighBeam Research, Signs of cerebral amyloid angiopathy-related inflammation reported.