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HIV-1 infection blocked via CCR5 and CXCR4 receptors.
2004 APR 21 - (NewsRx.com & NewsRx.net) -- HIV-1 infection was blocked via CCR5 and CXCR4 receptors by acting in trans on the CCR2 chemokine receptor.
"The identification of chemokine receptors as HIV-1 coreceptors has focused research on developing strategies to prevent HIV-1 infection. We generated CCR2-01, a CCR2 receptor-specific monoclonal antibody that neither competes with the chemokine CCL2 for binding nor triggers signaling, but nonetheless blocks replication of monotropic (R5) and T-tropic (X4) HIV-1 strains. This effect is explained by the ability of CCR2-01 to induce oligomerization of CCR2 with the CCR5 or CXCR4 viral coreceptors," investigators in Spain report.
"HIV-1 infection through CCR5 and CXCR4 receptors can thus be prevented in the absence of steric hindrance or receptor downregulation by acting in trans on a receptor that is rarely used by the virus to infect cells," wrote Jose Miguel Rodriguez-Frade and ...
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Source: HighBeam Research, HIV-1 infection blocked via CCR5 and CXCR4 receptors.